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Osteo Arthritis Knee clinical trials

View clinical trials related to Osteo Arthritis Knee.

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NCT ID: NCT05751564 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

"Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells

PANLAR-II
Start date: April 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to compare a newly developed off-the-shelf cryopreserved "ready to inject" Mesenchymal Stem Cell (MSC) product with the usual MSC preparation the investigators have used in knee osteoarthritis (OA) patients. Since usual MSC therapy requires cell manipulation in GMP (Good Manufacturing Practices)-type facilities, this new formulation would enable wider access to Cell therapy and Multicentric clinical trials in areas devoid of expensive facilities and equipment.

NCT ID: NCT05659979 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

Comprehensive Geriatric Assessment in Knee Osteoarthritis

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is the most common form of arthritis, and is characterized by joint pain and stiffness leading to functional decline and relevant loss in quality of life. The management of knee OA is demanded to several specialists, including general practitioners, rheumatologists, orthopedics and finally geriatricians. However, the exact role of geriatricians in the management of knee OA was poorly studied, whilst the comprehensive geriatric assessment (CGA) is widely used for preventing negative consequences in older people.

NCT ID: NCT05388994 Not yet recruiting - Pain Clinical Trials

Exercise-related Irisin on Inflammation and Pain

Start date: May 18, 2022
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is a chronic disease that usually starts with cartilage damage in weight-bearing joints and then causes pain and loss of function secondary to damage in surrounding tissues. Osteoarthritis, which is seen with a frequency of approximately 10% in men over the age of 60 and approximately 18% in women, ranks first among the diseases related to the joint. Many factors such as age, gender, obesity, physical activity, trauma, and genetic factors are involved in the etiology of the disease. In osteoarthritis, intra-articular production and destruction events can occur simultaneously, so it is a dynamic process. Among the joints in the lower and upper extremities, osteoarthritis is most common in the knee joint. Various approaches are used in the treatment, including drug therapy, hyaluronic acid injection, use of glucosamine and chondritis sulfate, exercises, physiotherapy applications, and diet applications for weight loss to reduce pain and increase physical function. Physiotherapy and rehabilitation are important treatment options in OA. Generally, range of motion exercises, strengthening exercises, and endurance exercises are applied to patients. An exercise program can be as effective as an NSAID in reducing pain. Decreased quadriceps muscle strength is a finding seen in patients with symptomatic knee OA. In addition, aerobic exercise has the potential to improve cardiovascular fitness, many of the comorbidities often associated with OA, such as diabetes, hypertension, and obesity. Because OA is a major public health problem, a less costly population-based approach is desirable. Therefore, the aim of this study was to investigate the effects of exercise-related irisin on inflammation and pain in patients with OA who underwent exercise.

NCT ID: NCT05290818 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

Total Versus Robotic Assisted Unicompartmental Knee Replacement

TRAKER
Start date: September 2022
Phase: N/A
Study type: Interventional

The purpose of this research is to compare the functional outcomes of patients with end stage medial compartment OA of the knee undergoing a conventional mTKA to those undergoing rUKA and to assess the associated cost economics of such technology.

NCT ID: NCT04750252 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

Safety and Tolerability of StroMelâ„¢ in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint

Start date: August 22, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this trial is to evaluate the safety and tolerability of autologous StroMelâ„¢ for the treatment of moderate to severe OA of the knee joint.

NCT ID: NCT04728581 Not yet recruiting - Insomnia Clinical Trials

Improving Sleep After TKA Using Mirtazapine and Quetiapine

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Use of mirtazapine and quetiapine for improvement of sleep quality after TKA

NCT ID: NCT04439019 Not yet recruiting - Obesity Clinical Trials

Group Education & Lifestyle Modification's Impact on Weight Loss & Quality Life of Patients With OA

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Patients referred to Calgary's Alberta Hip & Knee Clinic, while awaiting consultation with an orthopedic surgeon for hip or knee osteoarthritis, will be offered the opportunity to participate in a dietary counseling program with the goal of attaining weight loss prior to surgery. Those patients interested in participating in the program will be offered the opportunity to participate in the research trial.

NCT ID: NCT04351932 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

Start date: June 7, 2020
Phase: Phase 3
Study type: Interventional

Mesenchymal stem cells (MSC) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation. MSCs can be isolated from a variety of tissues, such as umbilical cord, bone marrow, and adipose tissue. The multipotent properties of MSCs make them a promising option for the treatment of osteoarthritis (OA). Bone marrow mesenchymal stem cells (BM-MSC) and adipose derived mesenchymal stem cells (AD-MSC) have been used separately to treat OA. The aim of the present study will be to compare in a randomized non blind controlled clinical trial 3 types of intra-articular injections containing MSC populations obtained from two clinically relevant sources: BM-MSC, AD-MSC and a combination of both BM-MSC and AD-MSC.

NCT ID: NCT04103502 Not yet recruiting - Clinical trials for Total Knee Arthroplasty

In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA

TKA PCR
Start date: May 2024
Phase:
Study type: Observational

In vivo knee kinematics will be assessed for 20 subjects that have been implanted with either a MicroPort Medial Pivot or DePuy Attune posterior cruciate retaining (PCR) total knee arthroplasty (TKA) by Dr. Russell Nevins of Nevada Orthopedic & Spine Center [this is the location from which participants will be recruited].

NCT ID: NCT04036266 Not yet recruiting - Clinical trials for Osteo Arthritis Knee

Clinical and Radiographic Outcomes of Medial Open-wedge High Tibial Osteotomy

Start date: October 1, 2019
Phase:
Study type: Observational

Osteoarthritis is a common degenerative disorder of the articular cartilage . Risk factors include genetics, female sex, past trauma, advancing age, and obesity. The diagnosis is based on a history of joint pain worsened by movement, which can lead to disability in activities of daily living . Diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. The potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. Obesity and alignment especially varus malalignment are recognized factors of a progressive disease. High tibial osteotomy (HTO) is a widely performed procedure, and good results can be achieved with appropriate patient selection and precise surgical technique. It is reported to be an effective treatment for varus knee osteoarthritis (OA) by redistributing the load line within the knee joint . With an HTO, the surgeon aims to change the coronal alignment of the leg in order to shift the center of force passing axially through the knee from the arthritic region of the knee towards the unaffected side. The amount of alignment correction to be performed is calculated before surgery based on the extent of knee arthrosis and on the alignment of the patient's lower limbs on long-leg weight bearing radiographs . Our study is focused on effectiveness of open wedge High tibial osteotomy on clinical and radiographic outcomes of patients with medial knee osteoarthritis.