Laser Therapy on Orthodontic Tooth Movement

Orthodontic Tooth Movement Clinical Trial

Official title:

The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04070170
• Other study ID #: Laser on tooth movement
• Status: Completed
• Phase: N/A
• Start date: February 1, 2014
• Est. completion date: September 16, 2019

Study information

• Verified date: September 2020
• Source: Pontifícia Universidade Católica de Minas Gerais
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: September 16, 2019
• Est. primary completion date: November 6, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 13 Years to 18 Years

Eligibility

Inclusion Criteria:

• Facial convexity

• Protrusion or biprotrusion of the incisors

• Dental crowding

• Healthy periodontal condition

• Satisfactory oral hygiene

Exclusion Criteria:

• Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months

• Skeletal crossbite

• Parafunctional habits

• Occlusal interference

Related Conditions & MeSH terms

• Bone Remodeling
• Laser Therapy
• Orthodontic Tooth Movement

Intervention

Device:
• Low-level Laser Therapy
Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons

Procedure:
• Orthodontic force
Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

Locations

Country	Name	City	State
Brazil	Pontifical Catholic University of Minas Gerais	Belo Horizonte	MG

Sponsors (1)

Lead Sponsor	Collaborator
Ildeu Andrade Jr.

Country where clinical trial is conducted

Brazil, 

References & Publications (5)

Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. — View Citation

Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009. — View Citation

Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013 Jan;28(1):41-7. doi: 10.1007/s10103-012-1059-6. Epub 2012 Feb 18. — View Citation

Kim SJ, Moon SU, Kang SG, Park YG. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009 Sep;41(7):524-33. doi: 10.1002/lsm.20792. — View Citation

Torri S, Weber JB. Influence of low-level laser therapy on the rate of orthodontic movement: a literature review. Photomed Laser Surg. 2013 Sep;31(9):411-21. doi: 10.1089/pho.2013.3497. Epub 2013 Jul 24. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed before canine retraction
Primary	Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 1 month of canine retraction
Primary	Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 2 months of canine retraction
Primary	Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 3 months of canine retraction
Secondary	Chemokine levels in the periodontal tissue after LLLT and orthodontic force	The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)	The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy