Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth

Status Completed

Clinical Trial Summary

Clinical Trial Description

A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars. Orthodontic tooth movement induces bone remodeling by various signaling pathways. The variations in miRNAs expression and their impact in inflammation and osteoclastogenesis during the various stages of orthodontic tooth movements is not fully understood. 58 patients requiring asymmetrical upper first premolar extraction for orthodontic purposes have been enrolled for this split-mouth study: the canines to be distalized on the extractive site are considered as the test group, the controlateral canines (on the side without first premolar extraction) areconsidered as normal controls. ;

Study Design

Related Conditions & MeSH terms

Orthodontic Tooth Movement

Clinical Trial Details

NCT number	NCT06023433
Study type	Interventional
Source	University of Catania
Contact
Status	Completed
Phase	N/A
Start date	May 15, 2020
Completion date	September 30, 2023

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Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms