Orthodontic Appliance Complication Clinical Trial
Official title:
Neurogenic Inflammation and Angiogenesis in the Human Dental Pulp in Response to Occlusal Interferences and Orthodontic Movements
This study measures SP, CGRP and VEGF expression in human dental pulp under occlusal trauma induced by occlusal interferences under moderate orthodontic forces or under a combination of occlusal trauma and moderate orthodontic forces because in clinical reality, patients under orthodontic treatment experience a combination of these stimuli on their pulp tissue.
Substance P (SP) and calcitonin gene-related peptide (CGRP) are neuropeptides that are
assembled in the cell bodies of the trigeminal nerve and are transported through axonal flow
to the nerve endings in human dental pulp, mainly in type-C nerve fibers and free nerve
endings, where they are released to fulfill important biological functions.
SP plays an important role in pulp tissue reparation because it stimulates angiogenesis using
direct mechanisms by modulating the growth of endothelial cells and fibroblasts through the
activation of growth factors such as VEGF and IGF-1 and stimulates cell migration and
proliferation to form mineralized tissue as a defense mechanism. It also uses indirect
mechanisms such as binding to granulocytes or macrophages, which allow cells with angiogenic
potential to be attracted.
CGRP has a key role in pulp reparation because of its angiogenic potential, which is linked
to endothelial cell stimulation via the cAMP-PKA pathway, promoting cell proliferation. It
boosts VEGF expression and stimulates focal adhesion kinase involved in the stabilization and
maturation of blood vessels. It can stimulate growth factors that act on fibroblasts, such as
HGF, IGF-1, and bFGF, and it can also produce an effect on odontoblast-like cells by
increasing BMP-2 expression and allowing cell proliferation after 24 h. This shows that it
can contribute to mineralized matrix formation
Angiogenesis is mediated by several growth factors, such as the VEGF. VEGF is released in the
pulp tissue as a response to a harmful stimulus to counteract emerging hypoxic areas
regulating oxygen and nutrients supply to cell populations by forming new blood vessels. VEGF
is present in endothelial cells, mast cells, macrophages, lymphocytes, undifferentiated
mesenchymal cells, fibroblasts, and odontoblast-like cells, and it controls neurogenic
inflammation and reparation processes in combination with SP due to its angiogenic potential.
SP, CGRP, VEGF expression can be altered by the masticatory function, occlusal trauma,
orthodontic movements, or a combination of occlusal trauma and orthodontic movements, which
often takes place in patients under orthodontic treatment.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05825742 -
Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment
|
N/A | |
Active, not recruiting |
NCT03696511 -
Miniscrews Primary Stability
|
N/A | |
Completed |
NCT05710874 -
A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.
|
N/A | |
Completed |
NCT03004196 -
Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans
|
Phase 1/Phase 2 | |
Completed |
NCT05818527 -
Effectiveness of Low Frequency Vibration on the Rate of Canine Retraction
|
N/A | |
Completed |
NCT03400111 -
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
|
N/A | |
Completed |
NCT06403033 -
Mini-implant-supported Twin-Block in Treating Patients With Class II Division 1 Malocclusion
|
N/A | |
Active, not recruiting |
NCT05026411 -
Food Reward Circuit Change by Orthodontics
|
N/A | |
Terminated |
NCT04604262 -
Does Use of the Waterpik Maintain Cleaner Teeth in Patients With Fixed Braces
|
N/A | |
Completed |
NCT02427763 -
Microbiological and Epithelial Evaluation Related to the Use of Orthodontic Thermoplastic Device
|
Phase 0 | |
Recruiting |
NCT05005689 -
Fluoride Delivery to Prevent White Spots During Orthodontic Treatment
|
Phase 4 | |
Recruiting |
NCT04606186 -
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
|
N/A | |
Completed |
NCT05499923 -
Quantitative Measurement of ARI
|
N/A | |
Completed |
NCT04037709 -
Photodynamic Therapy in Patients With Gingivitis
|
N/A | |
Recruiting |
NCT04598633 -
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment
|
N/A | |
Not yet recruiting |
NCT03653078 -
Root Proximity During Mini-Screw Insertion Using a Digital Three-Dimensional Printed Guide
|
N/A | |
Recruiting |
NCT05644119 -
Periodontal and Orthodontic Outcomes of Straight vs. Looped Fixed Retainers
|
N/A | |
Completed |
NCT05831722 -
Changes in the Upper Airway Volume After Rapid Maxillary Expansion in Adults Using Pure Skeletal Anchorage
|
||
Not yet recruiting |
NCT04131855 -
The Omission of Pumice Prophylaxis on Bracket Failure Rates Using Self Etch Primers
|
N/A | |
Completed |
NCT03476161 -
Bond Failure of Two Types of Molar Buccal Tubes
|
N/A |