Clinical Trials Logo

Opioid clinical trials

View clinical trials related to Opioid.

Filter by:
  • None
  • Page 1

NCT ID: NCT05732896 Active, not recruiting - Anesthesia Clinical Trials

Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery

NOLopioid
Start date: September 2, 2020
Phase: N/A
Study type: Interventional

In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery. The secondary goals are to compare the total dose hypnotic drugs, as well as hemodynamic parameters, and to investigate the relationship between changes in the NOL index and HR change following severe noxious stimuli during effect site TCI of propofol and remifentanil in patients undergoing intracranial tumor surgery who are monitored using either standard monitors or the NOL monitor additionally.

NCT ID: NCT05504265 Not yet recruiting - Esophageal Cancer Clinical Trials

Perioperative Analgesia Modes in Minimally Invasive Esophagectomy

Start date: August 10, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.

NCT ID: NCT05051189 Recruiting - OSA Clinical Trials

Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea

Start date: December 1, 2021
Phase: Early Phase 1
Study type: Interventional

Children OSA exhibit varying responses to opioids. It is unknown if the degree of intermittent hypoxemia results in different opioid sensitivity

NCT ID: NCT04011098 Terminated - Labor Pain Clinical Trials

Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour

Start date: July 1, 2019
Phase: Phase 1
Study type: Interventional

Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia. Current evidence suggests that epidural analgesia effectively manages pain in labour, but may give rise to adverse effects for both the mother and neonate. Opioids are often added to epidurals to improve the quality of analgesia. Despite reassuring findings regarding epidural opioids, other investigators have found an association between epidural opioids and neonatal respiratory distress, lower Neurological and Adaptive Capacity scores, and reduced rates of breastfeeding. Given the heightened implications for the mother and neonate in situations requiring induction of labour, the desire for a positive outcome whilst still providing adequate maternal analgesia is paramount. This study thus aims to investigate whether a preliminary epidural Fentanyl bolus at the initiation of the epidural may help to improve analgesia for women undergoing labour inductions for post-term pregnancy in a safe manner. Importantly, the main rationale of this proposed practice being that by achieving adequate epidural analgesia earlier in the labour induction, this may lead to better pain control overall and less overall requirements for epidural PCEA boluses and epidural "top-ups" as the induction progresses.

NCT ID: NCT03344042 Recruiting - Labor Pain Clinical Trials

Effect of Epidural Opioid Administered in the First A Period on the Progress of Labour

Start date: December 1, 2017
Phase: Phase 4
Study type: Interventional

Epidural anesthesia is used to relieve labour pain which helps reduce labour stress, increase comfort and improve cooperation with medical personnel. Administering opioid into the epidural space before cervical dilation of 4cm in the primigravida or 3cm in the multiparous can effectively reduce the pain levels with no effect on the labour progress. The aim of the study is to compare different opioids administered in this early labour stage.

NCT ID: NCT03223896 Completed - Gambling Clinical Trials

Treatment of Gambling Disorder With Fast Acting Opiate Antagonist, Naloxone Nasal Spray

NALPILO
Start date: February 14, 2017
Phase: Phase 2
Study type: Interventional

Non-controlled pilot study. Two groups: Group A: naloxone nasal spray max 8 mg/per day; Group B: naloxone max 16 mg/per day. Study duration 8 weeks. Brief intervention.

NCT ID: NCT00410644 Completed - Pain Clinical Trials

A Repeated-Dose Evaluation of a Pain Relieving Drug Use and Safety of OROS Hydromorphone HCI in Patients With Chronic Non-Malignant Pain

Start date: n/a
Phase: Phase 3
Study type: Interventional

The purpose of this repeated dose study is to develop recommended dosing information for initiation of therapy with OROS Hydromorphone in patients with chronic non-malignant pain converting from other strong oral or transdermal opioids. It will also assist in the development of a recommended starting dose by which patients can be titrated to an appropriate maintenance dose of OROS Hydromorphone HCI. The safety profile for OROS Hydromorphone HCI will also be evaluated.