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Oncology clinical trials

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NCT ID: NCT06031233 Recruiting - Oncology Clinical Trials

Evaluating the Safety of Shortened Infusion Times for dIfferent Oncological Immunotherapie

MINUTE
Start date: September 1, 2023
Phase: Phase 4
Study type: Interventional

This study is an interventional, explorative, prospective study to show whether shortening of infusion times for patients using nivolumab, pembrolizumab, ipilimumab, trastuzumab, bevacizumab, durvalumab or atezolizumab continues to be associated with an acceptable safety profile. Infusion times will be gradually shortened if tolerability allowes.

NCT ID: NCT05985083 Recruiting - Oncology Clinical Trials

A Study Of IMM47 In Subjects With Advanced Solid Tumors

Start date: August 18, 2023
Phase: Phase 1
Study type: Interventional

This is a first-in-human (FIH), open-label, multi-center, phase I study to evaluate the safety, tolerance, pharmacokinetics (PK), immunogenicity, preliminary anti-tumor activity, pharmacodynamics, and biomarker activity of IMM47 monotherapy in subjects with advanced solid tumors.

NCT ID: NCT05921279 Recruiting - Breast Cancer Clinical Trials

Understanding CARdiac Events in Breast Cancer

UCARE
Start date: January 14, 2023
Phase:
Study type: Observational

In Ireland, over 3,000 patients are diagnosed with breast cancer annually, and 1 in 9 Irish women will be diagnosed with breast cancer in their lifetime. There is evidence that female breast cancer survivors are more likely to die of cardiovascular disease than their age-matched counterparts. This research is focused on evaluating pathways for identifying, managing, and overcoming side effects of cancer therapies that can negatively impact quality-of-life and overall outcomes for women during and after cancer treatment. The Cardio-oncology research team at GUH plan to capitalize on their expertise in both cancer care and cardiology to develop a care pathway for cancer patients who are at increased risk of developing heart disease.

NCT ID: NCT05825794 Recruiting - Oncology Clinical Trials

Active Pharmacovigilance of Anti-cancer Medicines

Start date: October 28, 2021
Phase:
Study type: Observational

Pharmacovigilance (PV), defined by the World Health Organization (WHO) as the "science and activities related to the detection, evaluation, understanding and prevention of adverse effects or any other drug-related problem", aims to improve patient safety and quality of life. There are several objectives of PV, starting with the collection and management of safety data, to promote the safe and effective use of medicines. PV also aims to provide information on drug safety to health professionals and patients, and it contributes to updating drug labels. Finally, it is active in risk management, risk minimization and the prevention of adverse effects and other drug-related problems. As defined by WHO, an adverse event (AE) is "any untoward medical occurrence that may be present during treatment with a medicine, but which does not necessarily have a causal relationship with this treatment". When there is a causal relationship with the treatment, an AE is classified as an adverse drug reaction (ADR). The collection and reporting of AEs is a process that starts from the drug development phase and proceeds continuously throughout the life cycle of the drug, and it aims to assess the benefits-to-toxicity ratios (in other words, the safety and efficacy) of all medicines. Reports of ADRs must accurately describe the case and be meaningful to health professionals worldwide. The aim of this project is to evaluate the impact of an active prescription surveillance of anti-cancer drugs carried out by the clinical pharmacist in pediatrics and young adults.

NCT ID: NCT05821166 Recruiting - Oncology Clinical Trials

Potential of Moderate Whole Body Hyperthermia to Enhance Response

POWER
Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

Using moderate whole-body hyperthermia (mWBH) in tumor patients to see the influence on circulating tumor cells, tumor response, quality of life, fatigue, psyche, immune response and tumor microenvironment

NCT ID: NCT05810987 Recruiting - Oncology Clinical Trials

Remote Education Strategies Training Oncology Residents for End-of-Life Discussions

RESTORED
Start date: January 1, 2023
Phase: N/A
Study type: Interventional

Difficult conversations are common in oncology practice and patient-centered communication is essential to care for individuals with cancer. Within oncology training programs, communication training is mostly unstructured observation and feedback in the clinic and many learners receive inadequate training. Currently, educational resources are limited, and residents have indicated a desire for more education on end-of-life communication skills. A formal communication curriculum could fill a gap and help to standardize teaching and evaluation. The overall goal of this study is to establish an effective communication skills curriculum for oncology residents that can be delivered remotely and that addresses difficult conversations with cancer patients. Through this preliminary study, we will explore the feasibility of a randomized controlled trial comparing different training experiences to understand how best to help oncology residents develop strong end-of-life communication skills.

NCT ID: NCT05788809 Recruiting - Oncology Clinical Trials

Communication Skill and Related Factors Among Oncology Nurses

Start date: April 7, 2023
Phase:
Study type: Observational

This study is a 1-year quantitative method research.Data collection will be divided into oncology nurses and cancer patients.To explore the related factors of clinical oncology nurses on the psychological aspects of cancer patients.

NCT ID: NCT05781295 Recruiting - Children Clinical Trials

Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology

PEDIALOCK
Start date: January 19, 2024
Phase: N/A
Study type: Interventional

Interest of a Taurolidine lock at each catheter closure in the primary prevention of catheter-related endoluminal infection in paediatric oncology. Multicentric, controlled, randomized and double-blind label study.

NCT ID: NCT05776680 Recruiting - Cancer Clinical Trials

The Effects of Multi-Psycho-Oncology Care Courses

Start date: August 22, 2022
Phase: N/A
Study type: Interventional

When the patient's mood has not yet reached a moderate to high severity level, psychological support is usually provided by the clinical nurses. However, the result of past research showed that the needs of patients and their caregivers were not satisfied with the psychological level. Scholars pointed out that it may be related to factors such as excessive clinical workload or insufficient psychological support and care capacity. In addition, under the influence of COVID-19 in the past two years, medical staff are facing more physical and mental pressure. Oncology nurses have a heavy workload and are affected by the COVID 19 epidemic, which reflects that nurses need psychological support. Therefore, this study intends to reduce stress through remote physical and mental support activities, and use the Internet to intervene in guided relaxation and meditation. Considering the scheduling of clinical nurses, a remote and unstructured course content that does not require continuity will be selected, and then advanced to provide the empathetic care skills of oncology nurses.

NCT ID: NCT05738252 Recruiting - Frailty Clinical Trials

Frailty Assessments for Risk Assessment in Gynecologic Oncology Patients

FARGO
Start date: June 15, 2023
Phase:
Study type: Observational

FARGO is a prospective cohort study that aims to determine the performance of preoperative frailty assessment based on the Frailty Phenotype (FP), compared to a perioperative cardiovascular risk assessment based on the combination of preoperative Revised Cardiac Risk Index (RCRI), age and occurrence of myocardial injury after noncardiac surgery (MINS), in predicting the composite of all-cause death or new disability at 6 months after surgery in patients aged 55 or older. Patients will have confirmed or suspected gynecologic cancer, undergoing cytoreductive or high-risk surgery with or without chemotherapy.