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Old Age; Debility clinical trials

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NCT ID: NCT04297111 Completed - Muscle Weakness Clinical Trials

Probiotic-Muscle Study

Start date: November 25, 2019
Phase: N/A
Study type: Interventional

This study will examine the effect of probiotic supplementation (Bacillus coagulans) on muscle protein synthesis in older adults in response to a plant-based diet. The investigators hypothesize that probiotic supplementation will enhance the digestibility of plant protein, therefore increasing the proportion of ingested amino acids that appear in systemic circulation and enhancing rates of muscle protein synthesis.

NCT ID: NCT04283279 Not yet recruiting - Hearing Loss Clinical Trials

Exercise to Improve Balance in Older Adults With Hearing Impairment - a Proof-of-concept Study

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

Hearing impairment is common in older adults, and recent research points to associations between hearing impairment and balance/mobility. The association may be due to more attentional resources being used to compensate for the sensory loss, with less resources available for maintaining balance. The aim of this projects is therefore to investigate whether an exercise program with focus on motor-cognitive tasks is feasible for older adults with hearing impairment. The study is meant as a proof-of-concept study, where trialling will be evaluated, and results will be used to inform the design of a larger and adequately powered study.

NCT ID: NCT04165005 Completed - Clinical trials for Psychological Distress

Mindfulness-based Short Intervention for Seniors - Decentering Effects on Cognitive Functions and Psychological Distress

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The present study examined the effect of a short Mindfulness-based intervention emphasizing a 'decentering' component on elderly seniors. Methods: 30 community seniors (Mage= 74.7) performed either 'decentering' intervention, guided imagery intervention, or control care as usual. The 8-week interventions included weekly 20-minute sessions and daily 10-minute home practice. Participants underwent a cognitive and emotional assessment before and after the interventions, which included filling out questionnaires and performing the Simon task. Trial registration: The study follows the principles of the Declaration of Helsinki, approved by the committee in Beer-Yaacov Hospital, Israel (number 579) on 24 Oct. 2017.

NCT ID: NCT04139109 Completed - Fall Clinical Trials

The Turkish Version of the Survey of Activities and Fear of Falling in the Elderly

Start date: January 22, 2018
Phase:
Study type: Observational

The Survey of Activities and Fear of Falling in the Elderly (SAFE) was originally developed in English to determine the level of fear of falling and its interactions with activities of daily living. The purpose of this study was to translate and cross-culturally adapt the SAFE instrument into Turkish and investigate its psychometric properties.

NCT ID: NCT04134390 Completed - Old Age; Debility Clinical Trials

Study of Cabozantinib Efficacy, Safety and Tolerability in Metastatic Renal Carcinoma in Aged Fragile Patients: CABOMAYOR Study

CABOMAYOR
Start date: February 17, 2020
Phase: Phase 2
Study type: Interventional

Aged fragile patients are not usually included in clinical trials and efficacy and tolerability of the different available treatments in this population are unknown. Conversely, ageing has been associated with a decrease in the efficacy of immune checkpoint inhibitors due to a decline in the effectiveness of the immune system (immunosenescence). In the Checkmate 025 trial comparing nivolumab with everolimus, the Hazard Ratio (HR) in patients older than 75 years old favoured everolimus, 1.23 (0.66-2.31). Thus, TKis might be a better treatment option for this population. However, the absence of data and concerns about possible secondary effects associated, can preclude clinicians to treat aged fragile patients with cabozantinib. A pilot phase II trial would help to have data on safety and efficacy of cabozantinib in this aged fragile population. In METEOR trial around 60% of patients reduced the dose of cabozantinib because of toxicity and tolerance problems. It is suspected that the efficacy of cabozantinib in the population to be included in this trial (aged and fragile) will be similar to that observed in CABOSUN trial (disease control rate around 75%). However, there is no information available in this group of patients. On the other hand, in the >75 years old subgroup within the METEOR trial, 37% discontinued due to adverse events, 85% needed dose reductions and median average daily dose was 33,6 mg. For this reason, the cabozantinib initial dose chosen for patients to be included in this study is 40 mg/day.

NCT ID: NCT04091152 Recruiting - Satisfaction Clinical Trials

TIKeasy TAblet satisfaCtion (TikTac)

TikTac
Start date: September 19, 2019
Phase:
Study type: Observational

In the last ten years, gerontechnology is becoming an increasing topic in geriatric medicine. Nevertheless, there are still few studies assessing the usability of technologies in old patients, especially when they are hospitalized. Moreover, it has been shown that new technologies could be a source of ageism, thence the importance of involving the old people in the development of these technologies. Tik easy is a subsidiary of La Poste Company. Tik easy as designed a new tablet PC for old people. Research tends to show that the use of tablet PC can promote health and well-aging, and delay cognitive decline. In this study, we want to give a free access to "Ardoiz", the tablet PC designed by Tik easy, for old patients hospitalized in a geriatric acute care unit. The "Ardoiz" tablet PC allows to: - Maintain the family and social bond (send and receive messages, share photos and videos, call remotely between the patient and his family) - Discovering the Internet at his own pace (browse the Internet with daily updated contents such as news, content on cooking, music, etc.). - Prevent cognitive aging (stimulate cognitive abilities with the DYNSEO games). - Facilitate online administrative procedures.

NCT ID: NCT04083885 Completed - Aging Clinical Trials

Virtual Reality Training to Increase Rehabilitative Exercise in Seniors

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

Seniors are at risk for reduced independence and lowered quality of life after injury or illness. Gains in strength, stamina, balance, cardiovascular fitness and confidence resulting from regular exercise can help seniors to maintain (or improve) their functional ability, independence, and quality of life. However, seniors experience many barriers to exercise. The objective is to assess the use of virtual reality (VR) as a motivating way to encourage seniors to do regular rehabilitative exercise. Seniors who could benefit from rehabilitative exercise and who live in two situations, a) long-term care and b) independently in their homes, will be recruited. Participants will be randomized to usual activity (control) or usual activity plus VR exercise. Long-term care residents will do VR with the assistance of care staff or study partners under the direction of the research team. Independent-living participants will do VR in their homes with the supervision of study partners, under the direction of the research team. All participants will be asked to do VR 3-5 times a week for 8 weeks. Mobility (balance, gait, physical function), and health outcomes (falls, hospital admissions) will be assessed and compared over time.

NCT ID: NCT04057443 Recruiting - Clinical trials for Hematologic Malignancy

Nutritional and Physical Exercise Intervention in Older Patients With Malignant Hemopathies

ICOSENIORHEM
Start date: April 11, 2019
Phase: N/A
Study type: Interventional

Clinical trial to analyze the impact of nutrition and physical exercise intervention program on the completion of treatment in older patients 70 years or older with malignant hemopathology

NCT ID: NCT04045535 Completed - Chronic Pain Clinical Trials

Effectiveness of a Physical Activity Intervention for Pre-frail Older Adults With Chronic Pain.

Start date: June 6, 2018
Phase: N/A
Study type: Interventional

The purpose of this investigation is to evaluate the effectiveness of a multicomponent structured physical exercise program for adults aged 65 years or more, classified as pre-frail and with chronic pain to improve the Perceived Health Related Quality of Life, compared with usual care.

NCT ID: NCT04026802 Completed - Old Age; Debility Clinical Trials

Safety and Feasibility of a Novel In--Bed Resistance Training Device in Elderly Inpatients

Start date: August 27, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to decrease deconditioning of elderly inpatients in acute care institutions and to assess the safety and feasibility of a newly developed resistance training device. Investigators believe this device will help hospitalized seniors maintain their independence by preventing the loss of functionality from deconditioning and improve value of care through decreased length of stay and utilization of care. Current therapy will be complemented with a new in--bed resistance training device to target weak elderly patients and standardize progressive resistance training in facilities.