Breast Cancer Clinical Trial
Official title:
Proof-of-Concept Study of AZD4547 in Patients With FGFR1 or FGFR2 Amplified Tumours
To assess the activity of the FGFR inhibitor AZD4547 in patients with FGFR1 or FGFR2 amplified breast, squamous lung and stomach cancer whose cancers have progressed following previous chemotherapy
Primary endpoint
- To assess anti-tumour activity as change in tumour size at 8 weeks and the correlation
with change in tumour ERK1/2 phosphorylation at day 10-14.
Secondary endpoints
- Objective response rate to AZD4547 in all patients and in each tumour group
- Safety and tolerability of AZD4547 in all patients
- Disease control rate at 8 weeks
- Progression free survival in all patients and in each tumour group
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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