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Ocular Surface Disease clinical trials

View clinical trials related to Ocular Surface Disease.

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NCT ID: NCT04649177 Completed - Dry Eye Syndromes Clinical Trials

Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

Start date: December 15, 2020
Phase: N/A
Study type: Interventional

EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE (prosthetic replacement of the ocular surface ecosystem) devices could be replaced and/or strengthened with a more rapid, automated fitting sequence. This could considerably reduce the time needed per visit, the number of visits, and the number of devices needed to be manufactured to reach the endpoint. Additionally, the scanning technology may afford the opportunity to successfully fit some pathology that were previously treatment failures. The automated technology may as well reduce the intensive clinician training time needed to fit PROSE devices, therefore increasing the availability and access to patients. The goal of this research is to evaluate the reliability and efficacy of this automated technology for fitting PROSE devices. Data from real-time measurement of the human eye ocular surface topography will be used to fabricate a prosthetic lens. The fit of the PROSE device will be evaluated, as well as the subjective comfort of the fit.

NCT ID: NCT04536129 Completed - Glaucoma Clinical Trials

Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure

Start date: November 4, 2019
Phase: N/A
Study type: Interventional

Evaluation of the safety and efficacy of hydrocortisone eye drops in the treatment of OSD (ocular surface disease) patients with and without glaucoma.

NCT ID: NCT04535388 Completed - Clinical trials for Ocular Surface Disease

LK Scleral Lens for Patients With Intractable Ocular Surface Diseases

Start date: May 1, 2012
Phase: N/A
Study type: Interventional

Scleral lenses have emerged as an efficacious treatment option for various types of intractable ocular surface diseases with many advantageous results. The purpose of this study was to report the efficacy and safety of the LK scleral lenses and determine their suitability in Asian patients with intractable ocular surface diseases. Subjects with intractable ocular surface diseases are enrolled to fit LK scleral lenses for 12 weeks for a prospective study. Evaluations are performed at 1, 4, 8 and 12 weeks. General patient demographics and medical history, visual acuities, thorough ophthalmic evaluation, ocular surface disease index and National Eye Institute 25-Item Visual Function Questionnaire are collected for each patient.

NCT ID: NCT04493658 Completed - Dry Eye Syndromes Clinical Trials

Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye

Start date: January 11, 2021
Phase:
Study type: Observational

To investigate and compare the burden of dry eye in Sjögren's syndrome dry eye vs non-Sjögren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by tear fluid analysis and impression cytology.

NCT ID: NCT04452279 Completed - Clinical trials for Glaucoma, Open-Angle

Ocular Surface Disease Changes After iStent or iStent Inject Implantation With Phacoemulsification

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This prospective interventional single-arm trial evaluates measures changes in ocular surface disease parameters in eyes with mild to moderate open-angle glaucoma (OAG) on 1-4 glaucoma medications who undergo phacoemulsification and trabecular micro-bypass stent(s) implantation (iStent or iStent inject).

NCT ID: NCT04351100 Completed - Osteoarthritis Clinical Trials

Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients

Start date: October 1, 2019
Phase:
Study type: Observational

Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.

NCT ID: NCT03968731 Completed - Dry Eye Syndromes Clinical Trials

Meibomian Gland Dysfunction Management With ZEST Protocol

Start date: June 10, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate if cleaning the eyelid margin with the ZEST protocol (Zocular Eyelid System Treatment) in patients intolerant to contact lens wear consequent to Meibomian gland dysfunction (MGD) will improve the MGD and contact lens wear comfort.

NCT ID: NCT03945071 Completed - Dry Eye Clinical Trials

The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the effectiveness of punctal plugs in reducing ocular surface (eye surface) irritation after intravitreal injections prepared by povidone-iodine 5% solution.

NCT ID: NCT03923244 Completed - Dry Eye Syndrome Clinical Trials

Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface

C-SS0
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

The main objective is to describe the characteristics of dry eye syndrome before and after surgery at one month of cataract surgery, using a multimodal analysis of the ocular surface. The secondary objectives are to evaluate: - Predictive factors of dry eye syndrome during cataract surgery: - The characteristics of dry eye syndrome - Implications for the patient's quality of life

NCT ID: NCT03769454 Completed - Clinical trials for Ocular Surface Disease

A Phase I Study of PP-001 Eye Drops in Healthy Adult Volunteers

Start date: November 20, 2018
Phase: Phase 1
Study type: Interventional

In this study, PP-001 eye drops are assessed for safety and tolerability in healthy, adult volunteers. PP-001 is a novel, anti-inflammatory small molecule that inhibits a specific enzyme (Dihydroorotate Dehydrogenase). The study was amended and now includes patients with ocular surface inflammation.