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Ocular Hypertension clinical trials

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NCT ID: NCT04702789 Terminated - Ocular Hypertension Clinical Trials

Comparative Study of the Efficacy of Either Krytantek Ofteno PF® or Eliptic Ofteno PF® Plus Gaap Ofteno PF® for POAG or Ocular Hypertension.

PRO-122
Start date: October 19, 2021
Phase: Phase 4
Study type: Interventional

Phase IV randomized, double blind, multicenter, parallel group clinical study to evaluate the efficacy of the combined use of Krytantek Ofteno PF® and Gaap Ofteno PF®, both applied every 12 hours, versus the use of Eliptic Ofteno PF® Plus Gaap Ofteno PF®, both applied every 12 hours, in patients with open angle glaucoma or ocular hypertension during 90 days

NCT ID: NCT04639947 Terminated - Glaucoma Clinical Trials

Reliability and Reproducibility of the Eye Check Tonometer

EyeCheck
Start date: January 6, 2021
Phase: N/A
Study type: Interventional

To investigate whether the new applanation tonometer (EyeCheck monitor) can provide intraocular pressure (IOP) measurements comparable to those of traditional tonometers such as the Goldmann applanation tonometer and the Tonopen.

NCT ID: NCT04454190 Terminated - Glaucoma Clinical Trials

Development and Validation of a Model to Predict Fast Progression in Glaucoma

Start date: July 20, 2021
Phase:
Study type: Observational

1. The purpose of this study is to obtain genetic data on a well-defined population of patients with glaucoma that had accurate measurements of rates of structural and functional change over time. 2. The investigators aim to recruit 5,000 patients for Phase I and 100 patients for Phase II over a period of 2 years for obtaining blood samples which will be processed for extraction of DNA and genotyping. Phase II also includes eye examination. Patients will be selected from the Duke Glaucoma Registry (DGR) database and will be contacted by phone, mail or email using a standardized script and procedure. 3. Data analysis, based on patient-blind (no personal health information) data will take place at Duke and Genentech. No protected health information (PHI) will leave Duke. Standard statistical methods will be used to analyze the collected data and to develop predictive statistical models for fast progression in glaucoma. Risks from participating in the study are low and include loss of confidentiality and inherent issues related to drawing blood.

NCT ID: NCT04442464 Terminated - Ocular Hypertension Clinical Trials

Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if short-term wear of a spherical rigid contact lens, called a scleral lens, will raise intraocular pressure in ocular hypertensive patients.

NCT ID: NCT02891317 Terminated - Cataract Clinical Trials

Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma

Start date: May 8, 2017
Phase:
Study type: Observational

The purpose of this study is to assess how surgical interventions in glaucoma affect 24-hour intraocular pressure, 24-hour ocular perfusion pressure, optic nerve blood flow, and retinal oxygen saturation.

NCT ID: NCT02858284 Terminated - Ocular Hypertension Clinical Trials

Evaluation of Safety and Efficacy of TUG (Therapeutic Ultrasound for Glaucoma) in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate whether the TUG device is safe and effective in patients with primary open angle glaucoma or ocular hypertension.

NCT ID: NCT02801617 Terminated - Ocular Hypertension Clinical Trials

Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension

COMPLIANCE
Start date: September 2015
Phase: Phase 3
Study type: Interventional

Aim: To demonstrate the non-inferiority of the PRO-067 ophthalmic solution manufactured by Laboratorios Sophia S.A. de C.V. versus GAAP Ofteno® ophthalmic solution like hypotensive therapy in subjects with primary open angle glaucoma or ocular hypertension. Study design: a multicentric, prospective, crossover (2x2), double blind clinical study. Sample size: one hundred patients with primary open angle glaucoma or ocular hypertension. Patients in the period 1: In the first sequence 60 patients will be assigned to receive the ophthalmic solution: GAAP Ofteno ® (latanoprost 0.005%) 1 drop per day (QD) during 30 days and the second sequence 60 patients will be assigned to receive the ophthalmic solution: PRO-067 1 drop QD during 30 days in the same period. Washout period: 21 hours. Patients in the period 2: the pharmacological intervention change to the opposite therapy for 30 days.

NCT ID: NCT02730871 Terminated - Ocular Hypertension Clinical Trials

Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®

Start date: June 24, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the additive intraocular pressure (IOP) lowering effect of Brinzolamide 1%/Brimonidine 0.2% (SIMBRINZA®) dosed twice daily (BID) when added to Travoprost 0.004%/Timolol 0.5% (DUOTRAV®) in subjects with open-angle glaucoma or ocular hypertension.

NCT ID: NCT02231515 Terminated - Clinical trials for Glaucoma and Ocular Hypertension

Prospective,Randomized,Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG

Start date: April 2014
Phase: N/A
Study type: Interventional

A prospective, randomized, controlled study to assess efficacy, safety, and tolerability of selective laser trabeculoplasty vs. pattern laser trabeculoplasty in patients with open-angle glaucoma.

NCT ID: NCT02226094 Terminated - Clinical trials for Ocular Hypertension (OHT)

Safety and Efficacy of Deep Wave Trabeculoplasty (DWT) in Primary Open Angle Glaucoma and Ocular Hypertension

Start date: November 2013
Phase: Phase 1/Phase 2
Study type: Interventional

The primary purpose of this study is to investigate the safety and efficacy of bilateral DWT in subjects with POAG or OHT compared to active and sham controls. The secondary purpose of the study is to investigate the durability, repeatability, and does response of the same.