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Ocular Hypertension clinical trials

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NCT ID: NCT06144918 Completed - Ocular Hypertension Clinical Trials

Phase 2, Placebo-Controlled, Study Assessing the Safety and Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Patients With Elevated Eye Pressure

Start date: November 9, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to test in patients with glaucoma and elevated pressure in the eye. The main questions it aims to answer are: • ability to lower pressure in the eye • safety in the eye and the body of patients with elevated pressure in the eye. Patients will be randomly given either: - 0.5% (5 mg/mL) SBI-100 Ophthalmic Emulsion - 1.0% (10 mg/mL) SBI-100 Ophthalmic Emulsion - Placebo Ophthalmic Emulsion Patients will be tested before starting and will have one drop of the product placed into each eye twice a day for 14 days, by the site and by the patient. At the end of the study, researchers will compare the groups to see if there is a change from before use of SBI-100 Ophthalmic Emulsion to the end of study.

NCT ID: NCT05686421 Completed - Glaucoma Clinical Trials

Comfortable and Stabilizing Chin & Forehead Rest Attachment for Slit Lamp Configurations

Start date: March 30, 2023
Phase: N/A
Study type: Interventional

In this study, participants will be imaged using two Optical Coherence Tomography (OCT) devices: device N, a standard conventional OCT device with an invention (comfortable chin and forehead rest that can be adjusted to fit each individual's size) attached to the device; and device C, the standard conventional OCT device with no invention attached. The investigators will assess whether the chin and forehead rest attachment (invention) provides a more comfortable experience for patients.

NCT ID: NCT05495269 Completed - Glaucoma Clinical Trials

Safety and Tolerability Study of QLS-101 in Adolescents With Sturge-Weber Syndrome (SWS)-Related Glaucoma Due to Elevated Episcleral Venous Pressure (EVP)

Start date: November 23, 2022
Phase: Phase 2
Study type: Interventional

Open-label study of an investigational product (IP), QLS-101, with 28-day every morning (QAM) dosing to both eyes (OU) in adolescents with SWS who have clinical evidence of glaucoma and/or ocular hypertension (OHT) related to SWS elevated EVP in at least one eye.

NCT ID: NCT05495061 Completed - Clinical trials for Primary Open Angle Glaucoma, Ocular Hypertension

A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Start date: August 9, 2022
Phase: Phase 3
Study type: Interventional

To investigate whether the IOP lowering efficacy of STN1012600 ophthalmic solution 0.002% is non-inferior to that of latanoprost 0.005% in subjects with POAG or OHT after treatment for 4 weeks.

NCT ID: NCT05397600 Completed - Glaucoma Clinical Trials

Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients

Start date: June 22, 2022
Phase: Phase 3
Study type: Interventional

The main study purpose is to demonstrate the non-inferiority of T4032 compared to Lumigan® 0.01% in terms of efficacy.

NCT ID: NCT05333419 Completed - Ocular Hypertension Clinical Trials

Study of a Latanoprost Ocular Implant for Treatment of Open Angle Glaucoma or Ocular Hypertension.

Start date: March 4, 2022
Phase: Phase 1
Study type: Interventional

This is an open label, single dose (100 ng/day) study to assess the safety, tolerability and biodegradation of the PA5436 Latanoprost FA SR Ocular Implant in adults who have OAG or OHT.

NCT ID: NCT05304299 Completed - Supplement Clinical Trials

Alleviating Effects Against High Intraocular Pressure by Oral Intake of Cordyceps Cicadae Mycelia

Start date: March 10, 2020
Phase: N/A
Study type: Interventional

This study will investigate the effects of lowering intraocular pressure by oral intake of Cordyceps cicadae mycelia, to provide evidence-based data for high intraocular pressure relief.

NCT ID: NCT05181046 Completed - Glaucoma Clinical Trials

Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Timolol Maleate in Glaucoma Patients

Start date: November 6, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of microdrops vs. standard eyedrops of 0.5% timolol maleate in adults with primary open-angle glaucoma or ocular hypertension in terms of intraocular pressure-lowering efficacy and cardiovascular side effects.

NCT ID: NCT05022004 Completed - Ocular Hypertension Clinical Trials

A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Start date: December 20, 2021
Phase: Phase 3
Study type: Interventional

This is a randomized, Investigator-masked, multi-center, parallel group, therapeutic equivalence study with clinical endpoint.

NCT ID: NCT04972695 Completed - Glaucoma Clinical Trials

Validation of an Automatic Analysis Algorithm of the Probability of Glaucoma From Optic Disc Images

Start date: May 7, 2021
Phase:
Study type: Observational

Clinical, cross-sectional and prospective study to assess the images of the posterior pole of the retina of patients from the Glaucoma Unit of the IOBA and the Hospital Clínico Universitario de Valladolid during the period between May and December 2021. The aim of the project is to provide a sufficient number of images from posterior pole retinographies in patients with suspected glaucoma or with diagnosis of glaucoma in order to determine the sensitivity and specificity of an automatic glaucoma screening algorithm developed by the company Transmural Biotech S.L.