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Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA

Obstructive Sleep Apnea Clinical Trial

Official title:
Effect of Eszopiclone on Adherence to Continuous Positive Airway Pressure (CPAP) and Severity of Insomnia in Patients With Comorbidity Between Insomnia and Obstructive Sleep Apnea (COMISA)

Clinical Trial Summary

The comorbidity between obstructive sleep apnea (OSA) and insomnia (COMISA) is common, and associated with poorer sleep quality. CPAP adherence among COMISA patients is worst than among those with OSA only. The investigators will compare the effect of Eszopiclone 3mg or placebo for 14 days on adherence to CPAP after 30 days and after 6 months.

Clinical Trial Description

The comorbidity between OSA and insomnia (COMISA) is common. COMISA leads to additive impairment of quality of sleep and quality of life compared to patients with insomnia or OSA alone. Patients with COMISA demonstrate worse adherence to CPAP compared to patients with isolated OSA. The best therapeutic approach for patients with COMISA is still unclear. Hypnotics have not been tested among patients with COMISA and indication for CPAP. The investigators will compare the effect of Eszopiclone 3mg or placebo for 14 days on adherence to CPAP after 30 days and after 6 months. In addition, the investigators will assess the effect eszopiclone on insomnia severity, quality of life, anxiety. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06017921
Study type Interventional
Source University of Sao Paulo General Hospital
Contact Pedro R Genta, MD.
Phone 551126615486
Email prgenta@usp.br
Status Recruiting
Phase Phase 4
Start date August 24, 2023
Completion date December 20, 2025
View Details
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