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Endotypic Traits and Obstructive Sleep Apnea Surgery

Obstructive Sleep Apnea Clinical Trial

Official title:
Endotypic Traits and Obstructive Sleep Apnea Surgery

Clinical Trial Summary

This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

Clinical Trial Description

This is a prospective cohort (observational) study of 150 participants with moderate to severe obstructive sleep apnea (OSA) unable to tolerate positive airway pressure who are undergoing drug-induced sleep endoscopy (DISE), including measurement of upper airway closing pressure (Pclose), and tissue-repositioning soft palate surgery. Before and 6 months after surgery, the investigators will measure OSA severity (apnea-hypopnea index) with sleep studies (polysomnograms). Using a recently-validated polysomnography-based signal processing algorithm, the investigators will systematically assess the underlying mechanisms of OSA (traits) and airflow shape (consistent with palate obstruction). The expected 90 participants without resolution of OSA after surgery (surgery failures) will participate in an experimental randomized crossover study of acetazolamide (1 month) and acetazolamide/eszopiclone combination (1 month). Polysomnograms will be performed with each treatment, with algorithm-based determination of traits. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05953610
Study type Interventional
Source University of California, Los Angeles
Contact Eric J Kezirian, MD, MPH
Phone 32344257904242596559
Email EKezirian@mednet.ucla.edu
Status Recruiting
Phase Phase 2
Start date January 7, 2024
Completion date August 31, 2027
View Details
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