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Rescue Pharmacotherapy for OSA — RescOSA  

Obstructive Sleep Apnea Clinical Trial

Official title:
Treating Residual OSA With Endotype-directed Pharmacotherapy (Aim 3)

Clinical Trial Summary

Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of undertreated OSA. In this study, the investigators want to test the addition of a drug treatment to their regimen. Endotypes will be targeted pharmacologically with one of the following drugs: acetazolamide for a high loop gain, atomoxetine-plus-eszopiclone for poor pharyngeal muscle compensation, or trazodone for a low arousal threshold. This aim is expected to provide treatment strategies for rescuing non-responders to MAD or HGNS therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05293600
Study type Interventional
Source Brigham and Women's Hospital
Contact David Andrew Wellman, MD
Phone 5089827401
Email awellman@bwh.harvard.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date July 1, 2023
Completion date October 30, 2026
View Details
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