Obstructive Sleep Apnea Clinical Trial
Official title:
Randomized-Controlled Trial of Trazodone on Reducing Plasma sST2 Level and Neurodegeneration Progression in Patients With Amnestic Mild Cognitive Impairment and Obstructive Sleep Apnea
Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disease. Before progressing to AD, individuals may experience mild cognitive impairment (MCI). While these individuals with MCI have an increased risk of progressing to AD, emerging studies reveal that obstructive sleep apnea (OSA) is a risk factor for both MCI an well as AD. Thus, it is worthwhile to identify clinical management or interventions that retard the conversion of subjects with comorbid MCI and OSA and AD. A randomized, double-blind, placebo-controlled study proposed herein aims to examine the effect of trazodone on reducing level sST2 and protein markers that are associated with neurodegeneration in the plasma of subjects with comorbid OSA and MCI. In this 1-year study, 124 study participants will undergo a series of neurocognitive assessments.
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| NCT number | NCT05209035 |
| Study type | Interventional |
| Source | Chinese University of Hong Kong |
| Contact | Timothy Kwok |
| Phone | +852 3505 3173 |
| [email protected] | |
| Status | Not yet recruiting |
| Phase | Phase 4 |
| Start date | May 1, 2022 |
| Completion date | December 31, 2026 |
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