Evaluation of Trazodone in OSA-MCI

Status Recruiting

Clinical Trial Summary

Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disease. Before progressing to AD, individuals may experience mild cognitive impairment (MCI). While these individuals with MCI have an increased risk of progressing to AD, emerging studies reveal that obstructive sleep apnea (OSA) is a risk factor for both MCI an well as AD. Thus, it is worthwhile to identify clinical management or interventions that retard the conversion of subjects with comorbid MCI and OSA and AD. A randomized, double-blind, placebo-controlled study proposed herein aims to examine the effect of trazodone on reducing level sST2 and protein markers that are associated with neurodegeneration in the plasma of subjects with comorbid OSA and MCI. In this 1-year study, 124 study participants will undergo a series of neurocognitive assessments.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05209035
Study type	Interventional
Source	Chinese University of Hong Kong
Contact	Timothy Kwok
Phone	+852 3505 3173
Email	tkwok@cuhk.edu.hk
Status	Recruiting
Phase	Phase 4
Start date	May 10, 2022
Completion date	December 31, 2026

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