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Dilator Muscle Activity in Health and Sleep Apnea

Obstructive Sleep Apnea Clinical Trial

Official title:
Upper Airway Dilator Muscle Activity in Healthy Subjects and Patients With Obstructive Sleep Apnea During Wakefulness and Sleep

Clinical Trial Summary

The role of control of peri-pharyngeal muscle tone in the pathogenesis of obstructive sleep apnea (OSA) is obvious: pharyngeal obstruction occurs only during sleep; and pharyngeal collapse occurs in almost all healthy subjects during anesthesia. Better understanding of these control mechanisms may help identifying the central components of the pathogenesis of OSA.

Clinical Trial Description

Study plan: Subjects will be studied first during wakefulness, while breathing against external resistors, to evaluate how are the peri-pharyngeal muscles recruited and activated to prevent pharyngeal collapse in the presence of negative intra-pharyngeal pressures. Thereafter, the same parameters will be evaluated during sleep, to assess muscle recruitment during intra-pharyngeal obstruction. The investigaors will record the electromyogram (EMG) of several dilator muscles, as well as the pressures above and below the area of pharyngeal collapse, and airflow. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04254341
Study type Observational
Source Bnai Zion Medical Center
Contact
Status Enrolling by invitation
Phase
Start date September 2015
Completion date December 2022
View Details
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