The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation

Obstructive Sleep Apnea Clinical Trial

Official title: Does Dexmedetomidine Decrease the Incidence of Untoward Airway Events After Deep or Awake Extubation in Patients Undergoing Adenotonsillectomy With or Without Myringotomy and Tube Placement?

Status Terminated

Clinical Trial Summary

The investigators aim to investigate the effect of dexmedetomidine on the perioperative respiratory complications in this patient population undergoing both awake and deep tracheal extubation.

Clinical Trial Description

We propose a prospective double-blinded randomized controlled trial. 336 pediatric patients presenting to Massachusetts Eye and Ear Infirmary (MEEI) for adenotonsillectomy who are eligible for the study based on inclusion and exclusion criteria will be recruited. A Clinical Pharmacy specialist, will be in charge of preparing the dexmedetomidine and placebo doses and will randomize the patients to four equally numbered groups. The anesthesiologist will receive the assignment for the extubation method in a sealed envelope from the Clinical Pharmacy specialist. Multiple parameters will be recorded in perioperative period to quantify perioperative adverse respiratory events. ;

Related Conditions & MeSH terms

• Adenoiditis
• Adenotonsillar Hypertrophy
• Hypertrophy
• Obstructive Sleep Apnea
• Sleep Apnea, Obstructive
• Tonsillitis

• NCT number: NCT02162433
• Study type: Interventional
• Source: Massachusetts Eye and Ear Infirmary
• Status: Terminated
• Phase: Phase 4
• Start date: March 2015
• Completion date: April 23, 2018