Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

Obstructive Sleep Apnea Clinical Trial

Official title: Determining Predictors of Adequate Upper Airway Function in Ventilated Patients

Status Recruiting

Clinical Trial Summary

This is part 2 of the #NCT01618240 under the same IRB protocol #2010P001919. The primary objective of this study is to examine factors that are related to sleep-disordered breathing and upper airway patency in critically ill patients who have been recently mechanically ventilated. Our primary hypothesize is that sedatives and neuromuscular blocking agents given in the ICU prior to extubation and during the first night following extubation are associated with sleep-disordered breathing. The secondary hypotheses are that duration of mechanical ventilation, BMI, and muscle strength are associated with sleep-disordered breathing during the night after extubation.

The secondary objective is to evaluate if sleep-disordered breathing in the ICU can be predicted by standard pulmonary function testing in the ICU.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Critical Illness
• Critically Ill
• Obstructive Sleep Apnea
• Sleep Apnea, Obstructive

• NCT number: NCT02112604
• Study type: Observational
• Source: Massachusetts General Hospital
• Contact: Matthias Eikermann, MD, PhD
• Phone: 617-643-4408
• Email: MEIKERMANN@PARTNERS.ORG
• Status: Recruiting
• Phase: N/A
• Start date: July 2011
• Completion date: December 2016