Effects of PAP Treatment of OSA in Patients With Heart Failure

Obstructive Sleep Apnea Clinical Trial

— OSA-MRI  

Official title:

Effects of Positive Airway Pressure (PAP) Treatment of Obstructive Sleep Apnea (OSA) in Patients With Heart Failure

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01136122
• Other study ID #: 2009H0304
• Status: Terminated
• Phase: N/A
• First received: May 17, 2010
• Last updated: March 28, 2016
• Start date: April 2010

Study information

• Verified date: March 2016
• Source: Ohio State University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease.

Description:

Obstructive Sleep Apnea (OSA) has been seen frequently in persons who develop insulin resistance and heart disease. Insulin resistance is a condition in which the body produces insulin but does not use it properly. Insulin helps the body use glucose for energy. Insulin resistance increases the chance of developing type II diabetes and heart disease.

One method of treatment for OSA is with continuous positive airway pressure (CPAP). This treatment is given by a device named CPAP. There are many different types of CPAPs available on the market that are FDA approved.

The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease. This study will measure insulin resistance by testing the glucose level in the blood, and testing the levels of special protein found in blood, that are known to increase the sensitivity to insulin and decrease progression of heart disease. The heart disease will be measured by cardiac MRI. Glucose testing and cardiac MRI's are normal testing procedures for people who have OSA and heart disease, however will be conducted more frequently than normal and therefore are for research purposes. The specialized blood testing is for research purposes only.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 3
• Est. primary completion date: October 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• 18 and < 75 years of age.

• Apnea-hypopnea index (AHI) of at least 15/hr based on overnight polysomnography.

• New York Heart Association Class 3 or less.

• LV ejection fraction <45% based on a prior imaging study (as measured within one year of baseline studies).

• Absence of exacerbation of heart failure requiring hospitalization within the previous 3 mos.

• Optimal pharmacologic therapy at the highest tolerated dose [3].

Exclusion Criteria:

• Use of anti-diabetic medications

• Primary valvular heart disease

• Unstable angina

• Myocardial infarction, cardiac surgery, or revascularization procedure within the previous 3 months

• Uncontrolled hypertension defined as systolic blood pressure >160 mm Hg or diastolic blood pressure >100 mm Hg.

• Active smoking (Patient should not have smoked for at least 1 month prior to baseline studies and has the intention not to smoke for the duration of the study period)

• Use of illicit drugs

• Current use of home oxygen therapy

• Requirement for a bi-level machine to treat sleep apnea

• Use of corticosteroids

• Creatinine clearance < 30ml/min (calculated from serum creatinine)

• Pregnant women will be excluded as pregnancy interferes with glucose and adiponectin. Additionally the contrast used in the cardiac MRIs may be harmful to unborn babies. Females of child bearing potential must agree to use effective contraception during the trial.

• Any contraindication to CMR (Cardiovascular magnetic resonance) imaging such as ferromagnetic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, neurostimulator, allergy to gadolinium-based contrast, or severe claustrophobia. The standard FDA and OSUMC's screening guidelines for MRI safety will be followed.

• Inability or unwillingness to provide consent

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)

Related Conditions & MeSH terms

• Obstructive Sleep Apnea
• Sleep Apnea Syndromes
• Sleep Apnea, Obstructive

Intervention

Device:
• CPAP Treatment
Effective CPAP treatment for one month

Locations

Country	Name	City	State
United States	The Ohio State University Medical Center	Columbus	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
Ulysses Magalang MD

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Increase in circulating levels of adiponectin (Ad) and/or high-molecular-weight (HMW) Ad.		One month	No
Secondary	Increased levels of Ad and/or HMW Ad associate with improvements in insulin sensitivity and heart function in patients with known left ventricular (LV) systolic dysfunction.		One month	No