Obstructive Sleep Apnea Clinical Trial
Investigate the role of clinical parameters in predicting the severity of obstructive sleep apnea
During the last two decades the obstructive sleep apnea syndrome (OSAS) has been
increasingly recognized as a distinct clinical entity. This condition is caused by recurrent
upper airway obstruction during sleep, is manifest as loud snoring, arterial oxygen
desaturation, sleep fragmentation, and excessive daytime sleepiness1,2. Epidemiological
series have shown that about 4% of the population suffers from symptomatic OSAS that
requires treatment3–5. OSAS is associated with increased rates of many chronic diseases6,7
and is a serious and potentially life-threatening disorder that is far more common than
generally believed. Thus, untreated OSAS may pose a significant public health problem8.
Epidemiological data demonstrating the relationship between OSAS and cardiovascular
morbidity highlight the potential importance of early recognition and treatment9.
The mechanisms responsible for upper airway obstruction in patients with OSAS are highly
complicated and as yet not fully understood. Several causes for OSAS have been suggested. It
appears to result from a variable combination of anatomic and pathophysiologic factors, some
of which may be under genetic control10. The relaxation of upper airway musculature has been
studied in relation to OSAS11-13. Anatomic narrowing of the upper airway as a result of
alterations in craniofacial morphology or soft tissue enlargement, the Bernoulli effect,
sleep posture, age, male gender, and adipose tissue in the pharynx have been suggested in
the etiology of OSAS14-17.
Several studies have suggested that ethnicity may be an important risk factor in OSAS17–20.
Recent reports have suggested that Asian subjects with OSAS have a greater severity of
illness compared with white subjects21,22. Some studies reported that obesity is the
strongest risk factor for OSAS in middle-aged adults3,23,24. However, we have treated many
non-obese Taiwanese young adults with severe OSAS. Previous researches have suggested that
there may be differences in obesity and craniofacial anatomy as risk factors between Asians
and whites25 and that the etiology of OSAS in obese patients may be different from that in
non-obese patients16,26,27. It is still unclear whether there are differences in clinical
evaluation parameters between non-obese Asian patients with severe OSAS and simple snoring.
We hypothesized that there are predictor factors in routine clinical examinations for
diagnosis of OSAS in non-obese young adult patients. Therefore, the objectives of this study
are to compare the clinical parameters in non-obese patients with severe OSAS with those of
simple snorers and to find the risk factors for OSAS in a non-obese young adult Taiwanese
population.
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Allocation: Random Sample, Observational Model: Natural History, Time Perspective: Longitudinal
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