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Serotonin and the Upper Airway in Obstructive Sleep Apnea

Obstructive Sleep Apnea Clinical Trial

Official title:
Serotonin and the Upper Airway in Obstructive Sleep Apnea

Clinical Trial Summary

The purpose of this study is to determine if a certain medication, alone or combined with another medication, will increase muscle activity in the upper airway in people who do and people who do not have sleep apnea. The medications being studied are paroxetine, a commonly used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a dietary supplement without a prescription. Because the effects of paroxetine in previous studies were not very large, we will also study it combined with 5HTP to see if the effect on the upper airway muscles is greater.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00100464
Study type Interventional
Source VA Office of Research and Development
Contact
Status Completed
Phase Phase 4
Start date November 2000
Completion date December 2003
View Details
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