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Atomoxetine and Oxybutynin in Obstructive Sleep Apnea — ATOSA  

Obstructive Sleep Apnea (OSA) Clinical Trial

Official title:
Effect of Atomoxetine and Oxybutynin on Phenotype Traits and OSA Severity

Clinical Trial Summary

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. Until recently, the search for medicines to activate pharyngeal muscles in sleeping humans has been discouraging. However, exciting new animal research has shown that drugs with noradrenergic and antimuscarinic effects can restore pharyngeal muscle activity to waking levels. In this protocol the investigators will test the effect of atomoxetine (a norepinephrine reuptake inhibitor) and oxybutynin (an antimuscarinic drug) administered together on OSA phenotype traits and OSA severity during sleep.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02908529
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 2016
Completion date January 2018
View Details
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