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Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity. — EVO  

Obesity Clinical Trial

Official title:
The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.

Clinical Trial Summary

Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.

Clinical Trial Description

This study focuses on unraveling the fundamental differences in communication via extracellular vesicles (EVs) derived from fat cells and immune cells in terms of fat tissue storage location and sex among individuals with and without obesity. The study hypothesizes that the differences in EV profiles, originating from corresponding in vitro differentiated hMADS and ex vivo isolated adult fat cells and immune cells, among individuals with and without obesity can be related to sex and/or fat tissue storage location. Additionally, the effect of the isolated EVs on the blood-brain barrier function is also investigated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06444646
Study type Observational
Source Hasselt University
Contact Lisa Mennens
Phone +32 (0)499 / 72 29 93
Email lisa.mennens@uhasselt.be
Status Recruiting
Phase
Start date February 20, 2023
Completion date September 2025
View Details
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