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The Effect of Time-Restricted Eating in Cardiometabolic Health — TRE  

Obesity Clinical Trial

Official title:
The Effect of Time-Restricted Eating in Cardiometabolic Health

Clinical Trial Summary

Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05866406
Study type Interventional
Source Cambridge University Hospitals NHS Foundation Trust
Contact Maria Chondronikola
Phone 01223746784
Email mc2425@medschl.cam.ac.uk
Status Recruiting
Phase N/A
Start date November 1, 2023
Completion date August 31, 2028
View Details
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