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Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals With Obesity and NAFLD — BRAVO  

Obesity Clinical Trial

Official title:
Assess the Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals With Obesity and Non-alcoholic Fatty Liver Disease

Clinical Trial Summary

This multicenter, double-blinded, randomized controlled trial aims to evaluate the effect of berberine in reducing visceral and liver adipose tissue among individuals with obesity and non-alcoholic fatty liver disease (NAFLD) in China.

Clinical Trial Description

The trial aims to evaluate the efficacy and safety of berberine treatment for obesity and NAFLD. Potential eligible patients will be recruited from 10-20 medical centers in China. After a 4-week run-in period with berberine, all the eligible participants will be randomized (1:1) to berberine 1.0 g per day plus lifestyle intervention (Arm A) or placebo plus lifestyle intervention (Arm B). The participants will be asked to attend the visit at least once every 2 months, and be followed up for 6 months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05647915
Study type Interventional
Source China National Center for Cardiovascular Diseases
Contact Haibo Zhang, MD
Phone +86 60866781
Email zhanghaibo@fuwai.org
Status Not yet recruiting
Phase Phase 4
Start date December 15, 2022
Completion date December 15, 2023
View Details
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