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NCT05518422 Clinical Trial

Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity

Obesity Clinical Trial

Official title:
Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT05518422
Other study ID # 2090413
Secondary ID
Status Withdrawn
Phase Early Phase 1
First received
Last updated
Start date February 2024
Est. completion date February 2024

Study information
Verified date February 2024
Source University of Missouri-Columbia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this project is to determine role for ET-1 in individuals with obesity.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date February 2024
Est. primary completion date February 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 55 Years
Eligibility Inclusion Criteria: - 18-55 years of age - Male sex - Obese (BMI =30 kg/m2) Exclusion Criteria: - Female sex - Current smoking/Nicotine use - Nerve/neurologic disease - Cardiovascular, hepatic, renal, respiratory disease - Blood pressure =140/90 mmHg - Diabetes - Vigorous exercise >3 times/week - Communication barriers - taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Hyperinsulinemic, euglycemic infusion
60 minute infusion

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University of Missouri-Columbia

Outcome
Type Measure Description Time frame Safety issue
Primary Amount of muscle sympathetic nerve activity (MSNA) MSNA burst incidence (bursts/100 heart beats) Change from baseline at minute 60
Primary Amount of leg blood flow Measured with Doppler ultrasound (mL/min) Change from baseline at minute 60
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