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Clinical Trial Summary

The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will comprehensively analyze glucose homeostasis in prediabetic patients treated for 14 weeks with mirabegron, tadalafil or both drugs as compared to a placebo.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05051436
Study type Interventional
Source University of Kentucky
Contact Douglas Long, M.S.
Phone 859-323-5438
Email delong2@uky.edu
Status Recruiting
Phase Phase 4
Start date December 13, 2021
Completion date February 28, 2025

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