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Effect of Hydroxychloroquine Sulphate in Healthy Lean Females — PLAQHV  

Obesity Clinical Trial

Official title:
The Effect of Hydroxychloroquine Sulphate on Hedonic Food Intake, Appetite-related Sensations and Gastrointestinal Hormone Release in Healthy Female Subjects

Clinical Trial Summary

The effect of an acute administration of hydroxychloroquine sulphate will be investigated on hedonic food intake, appetite related sensations and gastrointestinal hormone release in healthy female subjects.

Clinical Trial Description

Intragastric administration of a quinine-solution has shown to decrease hedonic food intake in healthy female volunteers. The effect of a tablet containing hydroxychloroquine sulphate on hedonic food intake in overweight female individuals has not been studied to date. The primary outcome of the current study is to evaluate the effect of hydroxychloroquine sulphate on hedonic food intake, assessed by ad libitum food intake of a chocolate milkshake one hour after dosing. The study is a randomized, placebo-controlled, double blinded cross-over study. Ten healthy lean females will be recruited as a proof of concept, before testing hydroxychloroquine sulphate in overweight female subjects. An acute dose of 400 mg hydroxychloroquine sulphate will be administered. Blood samples will be collected at regular time points to measure gastrointestinal hormone release and whole blood glucose levels. Appetite-related sensations will be scored at regular time points on visual analog scales. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04005768
Study type Interventional
Source Universitaire Ziekenhuizen Leuven
Contact Wout Verbeure
Phone 16373765
Email wout.verbeure@kuleuven.be
Status Not yet recruiting
Phase Phase 4
Start date August 1, 2019
Completion date October 1, 2019
View Details
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