Environmental Health Effects on Your Physiology — HYPHY  

Obesity Clinical Trial

Official title: Exposure to Air Pollutants and Green Space: Implications for the Gut Microbiome and Metabolome in Young Adults Living in Denver, Colorado

Status Active, not recruiting

Clinical Trial Summary

This study evaluates the associations between exposure to air pollutants, green space, and the gut microbiome and metabolome.

Clinical Trial Description

A rapidly evolving field of study suggests a link between the gut microbiome and fecal metabolome with obesity. Recent studies show that environmental exposures, such as ambient air pollution (AAP) exposure can affect gut bacteria and modify risk for obesity. Additionally, proximity to green space has been shown to reduce exposure to air pollutants and increase gut microbial diversity. The investigator's preliminary work has shown that near-roadway air pollution exposure was positively correlated with gut microbial taxa that have been linked with obesity. These findings suggest that air pollution exposure may increase susceptibility to obesity through alterations in the composition and function of the gut microbiome. Despite this, no studies have systematically examined the impact of air pollutants and green space on the gut microbiome and metabolome among adolescents. The overall goal of this research is to determine whether exposure to air pollutants and/or green space affect the gut microbiome and metabolome in young adults residing in Denver, Colorado. This study will examine residential-based estimates of air pollution exposure and green space and also perform detailed gut microbial and metabolite profiling in 100 adolescent and young adults. ;

Related Conditions & MeSH terms

• Obesity

• NCT number: NCT03986814
• Study type: Observational
• Source: University of Colorado, Boulder
• Status: Active, not recruiting
• Start date: July 18, 2019
• Completion date: December 30, 2023