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Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

Obesity Clinical Trial

Official title:
Cognitive-Behavioral and Pharmacologic Treatment of Binge-Eating Disorder and Obesity

Clinical Trial Summary

This study will test the relative efficacy and effectiveness of the combination of naltrexone and bupropion (NB) medication as a treatment for binge-eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst non-responders to acute treatments, NB medication results in superior outcomes compared with placebo.

Clinical Trial Description

Obesity is a heterogeneous problem and research has highlighted the particular significance of a subgroup with binge-eating disorder (BED), the most prevalent formal eating disorder. Improved treatments for patients with obesity and BED are needed that can produce sustained clinical outcomes and promote weight loss. This study RCT will provide new and novel findings from a controlled test, amongst non-responders to acute treatments, whether Naltrexone/Bupropion medication results in superior and longer-term outcomes than placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03946111
Study type Interventional
Source Yale University
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date August 7, 2019
Completion date December 14, 2023
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