Obesity Clinical Trial
Official title:
The Effect of Quinine on Food Intake: Oral Sham Feeding Versus Intragastric Delivery
Rationale: The appearance of tastants in the small intestine following food ingestion results
in the onset of digestion and absorption but can also result in the activation of a negative
feedback mechanism from different parts of the intestine to the stomach, the small intestine
and to the central nervous system. These processes inhibit food processing, appetite
sensations and food intake, and furthermore they increase feelings of satiety and satiation.
In this study, we aim to investigate the effects of oral sham feeding and intragastric
delivery of a bitter tastant (quinine) on ad libitum food intake, satiation, gastrointestinal
symptoms, and heart rate variability.
Objective: To investigate the effect of oral sham feeding and intragastric delivery of a
bitter tastant on food intake.
Secondary Objective(s):
1. To compare the effect of oral sham feeding and intragastric delivery of a bitter tastant
on satiation.
2. To assess the effect of oral sham feeding and intragastric delivery of a bitter tastant
on gastrointestinal symptoms/complaints.
3. To assess the effect of oral sham feeding and intragastric delivery of a bitter tastant
on heart rate variability.
n/a
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