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Trial of Roflumilast in Asthma Management (TRIM) — TRIM  

Obesity Clinical Trial

Official title:
Trial of Roflumilast in Asthma Management (TRIM)

Clinical Trial Summary

There are currently no treatments to specifically target asthma in obese adults. This pilot study is being conducted to investigate how effective roflumilast is in treating asthma in participants that have a higher BMI. Roflumilast can induce weight loss, which may lead to improved asthma control. The primary objective of TRIM is to perform a pilot placebo-controlled trial of roflumilast for the treatment of poorly controlled obese asthmatics.

Clinical Trial Description

TRIM is a 24 week, randomized, double-masked, placebo controlled trial that will enroll 38 participants. This study will be take place in seven centers of the American Lung Association- Airways Clinical Research Centers (ALA-ACRC). The centers include: Northwestern University Feinberg School of Medicine, Mount Sinai Icahn School of Medicine, Duke University, University of Arizona, the University of Vermont, The University of Alabama Lung Health Center, and University of Illinois Breathe Chicago Center. Johns Hopkins University will be the Data Coordinating Center (DCC) for the trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03532490
Study type Interventional
Source Johns Hopkins University
Contact
Status Completed
Phase Phase 2
Start date August 3, 2018
Completion date July 30, 2021
View Details
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