Obesity Clinical Trial
— i-FLEXOfficial title:
Sprint Interval Training: Insulin Sensitivity and Acute-Chronic Metabolic Flexibility in Individuals Living With Obesity: The i-FLEX Study
Verified date | March 2020 |
Source | University of New Brunswick |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Regular exercise is a cornerstone in the prevention and the management of cardio-metabolic
risk factors. Some of the beneficial effect of exercise training occurs through metabolic
flexibility' enhancement. Metabolic flexibility is the ability to respond or adapt to
conditional changes in metabolic demand, and previous literature has shown that individuals
living with obesity have an impaired metabolic flexibility compared to lean individuals.
However, there is a lack of empirical evidence on the impact of sprint interval training on
metabolic flexibility and whether this translates into clinically meaningful outcomes.
This study will evaluate the impact of 4-week sprint interval training in normal weight
individuals as well as individuals living with obesity on acute and chronic metabolic
flexibility, irisin secretion and insulin sensitivity.
Status | Completed |
Enrollment | 34 |
Est. completion date | February 28, 2020 |
Est. primary completion date | February 28, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 19 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Adults (Ages 19-60) - Physically inactive for individuals living with obesity (not meeting Canadian Physical Activity Guidelines) - Normal Weight (BMI = 18.5 < 25.0 km/m2) - Obesity (BMI = 30.0 km/m2) Exclusion Criteria: - Individuals with Type 2 Diabetes. - Individuals with impaired glucose tolerance. - Individuals living with obesity that partake in regular exercise training / meet the Canadian Physical Activity Guidelines. - Individuals with a condition or injury that may impact the ability to perform exercise or may be worsened by exercise. - Individuals currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism. - have experienced >10% weight loss or enrolled in weight loss program within six months of enrolment. - require use of medication(s) known to affect insulin sensitivity or secretion within the last 30 days. - Medication(s) known to cause weight gain. - weight loss medication(s). |
Country | Name | City | State |
---|---|---|---|
Canada | University of New Brunswick - Kinesiology | Fredericton | New Brunswick |
Lead Sponsor | Collaborator |
---|---|
University of New Brunswick |
Canada,
Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 2014 Dec 4;159(6):1253-62. doi: 10.1016/j.cell.2014.11.034. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Metabolic Flexibility | Chronic and acute metabolic flexibility will be quantified from the respiratory quotient (RQ) at rest and from the respiratory exchange ratio (RER) during a 4-6 minutes steady rate exercise bout. | Baseline and post-intervention (4 weeks) | |
Primary | Change in Insulin Sensitivity | Insulin sensitivity will be measure with the Matsuda Index | Baseline and post-intervention (4 weeks) | |
Secondary | Change in Irisin | This hormone will be quantified in the plasma during one acute session of exercise. | Baseline and post-intervention (4 weeks) |
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