Evaluation of Periodontal Diseases and Obesity in Women

Obesity Clinical Trial

Official title:

The Effects of Obesity and Periodontitis on Biochemical Parameters in Women Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03442920
• Other study ID #: 114S144
• Status: Completed
• Phase: N/A
• First received: February 9, 2018
• Last updated: February 21, 2018
• Start date: December 29, 2014
• Est. completion date: January 10, 2016

Study information

• Verified date: February 2018
• Source: Kocaeli University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

Description:

It is thought that adipokines may play a role on periodontal disease in obese subjects, periodontal disease may also aggravate the existing systemic disease by changing the inflammatory parameters in the body. The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

Recruitment information / eligibility

• Status: Completed
• Enrollment: 71
• Est. completion date: January 10, 2016
• Est. primary completion date: June 11, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Being women,

• Older than 18 yrs old,

• Not being pregnant,

• Not being disabled,

• For study group; being obese, not for healthy group being systemically health and in normal weight

• Not treated periodontological in the last 6 months

Exclusion Criteria:

• Younger than 18 yrs old,

• Smokers who smokes more than 10 cigarettes in a day,

• Uncontrolled systemic diseases,

• Having periodontal treatment

• who needs antibiotic prophylaxis

Related Conditions & MeSH terms

• Gingival Diseases
• Obesity
• Periodontal Diseases

Intervention

Other:
• Exercise
This group made exercise for 12 week/3 times a week.

Locations

Country	Name	City	State
Turkey	Kocaeli University	Kocaeli

Sponsors (2)

Lead Sponsor	Collaborator
Kocaeli University	The Scientific and Technological Research Council of Turkey

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biochemical variables GCF	TNF-A, IL-1B,concentrations levels (pg/µl)	12 week
Primary	Biochemical variables GCF	Leptin, adiponectin, resistin concentrations levels (ng/µl)	12 week
Secondary	Biochemical variables_Saliva	TNF-A, IL-1B,concentrations levels (pg/µl)	12 week
Secondary	Biochemical variables_Saliva	leptin, adiponectin, resistin concentrations levels (ng/µl)	12 week
Secondary	Biochemical variables_Serum	TNF-A, IL-1B,concentrations levels (pg/µl)	12 week
Secondary	Biochemical variables_Serum	leptin, adiponectin, resistin concentrations levels (ng/µl)	12 week