The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases

Obesity Clinical Trial

— QFS  

Official title:

The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03355729
• Other study ID #: 2010-075 CG
• Status: Completed
• Phase: N/A
• First received: November 16, 2017
• Last updated: November 27, 2017
• Start date: June 1978
• Est. completion date: September 5, 2002

Study information

• Verified date: November 2017
• Source: Laval University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.

Description:

The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992. During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited. During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited. During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 951
• Est. completion date: September 5, 2002
• Est. primary completion date: September 5, 2002
• Gender: All
• Age group: 10 Years and older

Eligibility

Inclusion Criteria:

• Age over 10 years

Exclusion Criteria:

Related Conditions & MeSH terms

• Obesity
• Physical Fitness

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Louis Pérusse	Canadian Institutes of Health Research (CIHR)

References & Publications (1)

Chaput JP, Pérusse L, Després JP, Tremblay A, Bouchard C. Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights. Curr Obes Rep. 2014 Jan 4;3:54-66. doi: 10.1007/s13679-013-0086-3. eCollection 2014. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body composition	Body composition as assessed by underwater weighing	Through study completion, an average of 24 years
Primary	Body mass index (kg/m^2)	Body mass index assessed from height and weight	Through study completion, an average of 24 years
Primary	Abdominal fat	Abdominal fat as assessed by commuted tomography	Through study completion, an average of 24 years
Primary	Waist and hip circumferences (cm)	Waist and hip circumferences (cm)	Through study completion, an average of 24 years
Secondary	Caloric intake	Total caloric intake and macronutrient intake using a 3-day dietary record	Through study completion, an average of 24 years
Secondary	Eating behaviour	Eating behaviour assessed using the Three-Factor Eating questionnaire	Through study completion, an average of 24 years
Secondary	Energy expenditure	Oxygen consumption at rest and during exercise	Through study completion, an average of 24 years
Secondary	Physical activity level	Physical activity level assessed by questionnaire	Through study completion, an average of 24 years
Secondary	Blood pressure (mm Hg)	Systolic and diastolic blood pressure	Through study completion, an average of 24 years
Secondary	Plasma lipid levels (mmol/L)	Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L	Through study completion, an average of 24 years
Secondary	Glucose levels (mmol/L)	Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers.; Plasma glucose levels in a fasting state and during an oral glucose tolerance test	Through study completion, an average of 24 years
Secondary	Insulin levels (pmol/L)	Plasma insulin levels in a fasting state and following an oral glucose tolerance test.	Through study completion, an average of 24 years
Secondary	C-reactive protein (CRP in mg/ml)	C-reactive protein (CRP in mg/ml)	Through study completion, an average of 24 years
Secondary	Adiponectin levels (in micrograms/ml)	Adiponectin levels (in micrograms/ml)	Through study completion, an average of 24 years
Secondary	Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml	Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml	Through study completion, an average of 24 years
Secondary	Smoking habits (nb of cigarettes per day)	Smoking habits (nb of cigarettes per day)	Through study completion, an average of 24 years
Secondary	Sleeping (hours/day)	Sleeping (hours/day)	Through study completion, an average of 24 years
Secondary	Alcohol consumption	Alcohol consumption (nb of drinks per week)	Through study completion, an average of 24 years

External Links

•   PubMed citation