HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents

Obesity Clinical Trial

Official title:

Effects of High-intensity Interval Training on Cardiorespiratory Performance and Substrate Oxidation in Insulin-resistant and Insulin-sensitive Obese Adolescents: A Before-and-after Clinical Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03042234
• Other study ID #: japarecido
• Secondary ID: 34634414.5.0000.
• Status: Completed
• Phase: N/A
• Start date: July 8, 2017
• Est. completion date: November 2, 2018

Study information

• Verified date: July 2021
• Source: Faculdade de Ciências Médicas da Santa Casa de São Paulo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

Description:

Objective: To evaluate the effect of high-intensity interval training (HIT) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 2, 2018
• Est. primary completion date: August 30, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 12 Years to 16 Years

Eligibility

Criteria

Inclusion Criteria:

• aged 12-16 years
• with a body mass index z-score (zBMI) = + 2SD
• puberty stage > 3
• the boys and girls had to present a minimum physical fitness, according to the International Physical Activity Questionnaire (IPAQ), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (VO2).

Exclusion Criteria:

• individuals undergoing drug treatment for weight control;
• indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Related Conditions & MeSH terms

• Adolescents
• Insulin-resistant
• Obesity

Intervention

Other:
• Group Insulin-Resistant
High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.
• Group Insulin-Sensitive
High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.

Locations

Country	Name	City	State
Brazil	Emef Angelina Maffei Vita	Sao Paulo
Brazil	Santa Casa of Sao Paulo School	Sao Paulo
Brazil	Emef Plinio Queroz	São Paulo

Sponsors (1)

Lead Sponsor	Collaborator
Faculdade de Ciências Médicas da Santa Casa de São Paulo

Country where clinical trial is conducted

Brazil, 

References & Publications (35)

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* Note: There are 35 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	rate of Peak oxygen consumption (VOpeak)	The cardiopulmonary test protocol for determination the VOpeak (ml/kg/min) included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion.; We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).	4 weeks
Primary	rate of Intensity at first ventilatory anaerobic threshold (VAT1)	The cardiopulmonary test protocol included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion.; We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).We determined VAT1 (ml/kg/min) using the V-slope method of Beaver et al.	4 weeks
Primary	rate of Peak Heart rate	The cardiopulmonary test protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil). speed of 4 km / h with increments of 1 km / h every minute until the participant shows exhaustion.	4 weeks
Primary	rate of carbohydrate oxidation	The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).	4 weeks
Primary	rate of lipid oxidation	The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).	4 weeks