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Short Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients

Obesity Clinical Trial

Official title:
Short Term Weight Loss With Liraglutide and Metformin Before IVF in Infertile Obese PCOS Patients

Clinical Trial Summary

The aim of this study was to evaluate the impact of short-term weight reduction achieved with 12-week intervention with metformin alone or in combination with liraglutide on oocyte maturity and embryo quality in infertile obese PCOS population.

Clinical Trial Description

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, in particular when PCOS is linked to obesity. Obese PCOS has poor IVF outcomes associated with impaired oocyte and embryo parameters and morphology. The purpose of this pilot prospective study was to investigate the effect of the antiobesity medical therapy (combination of metformin and liraglutide (COMBI)) on short time weight loss in the specific infertile obese PCOS population. Additionally, we analyzed eventual impact of the short term weight loss 5% or more before IVF on oocyte maturity and embryo quality in infertile obese PCOS population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03034941
Study type Interventional
Source University Medical Centre Ljubljana
Contact
Status Completed
Phase Phase 4
Start date April 2014
Completion date December 2016
View Details
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