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NCT02902198 Clinical Trial

Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

Obesity Clinical Trial

Official title:
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02902198
Other study ID # fMRI Taste 2
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 2014
Est. completion date December 2024

Study information
Verified date May 2023
Source University Hospital, Basel, Switzerland
Contact Bettina Wölnerhanssen, Dr
Email bettina.woelnerhanssen@usb.ch
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Recruitment information / eligibility
Status Recruiting
Enrollment 16
Est. completion date December 2024
Est. primary completion date December 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 55 Years
Eligibility Inclusion Criteria: - morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery - right handed Exclusion Criteria: - cardiovascular disease - neurologic/psychiatric disorders

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Placebo
Tap water 200ml
• Glucose
25g Glucose in 200ml tap water
• Monosodium glutamate
1g monosodium glutamate in 200ml tap water
• Quinine
17mg quinine in 200ml tap water

Locations
Country Name City State
Switzerland University Hopital Basel Basel

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Effect of tastants on cerebral blood flow measured by functional brain MRI changes from baseline to one hour after treatment
Secondary Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations changes from baseline to one hour after treatment
Secondary Effect of tastants plasma ghrelin concentrations changes from baseline to one hour after treatment
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