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Clinical Trial Summary

The research aims to compare the inflammatory status of visceral adipose tissue from obese patients depending on the presence and severity of periodontitis, in order to establish a potential causal link between the severity of the bacterial contamination and insulin resistance.


Clinical Trial Description

Recruitment of patients will be achieved in the department of digestive surgery. It will involve 122 patients with severe obesity undergoing bariatric surgery scheduled within the digestive surgery department. Patients recruited will be examined for evaluating the presence and severity of periodontitis, and separated into either group 1: for patients with moderate or severe periodontitis, and or group 2: for patients without or with mild periodontitis. The day before the surgery, blood sample will be collected for the analysis of circulating metabolic and inflammatory markers. Collection of stimulated saliva, periodontal sample and faeces samples (50 g) will also be carried out for bacteria determination. During the surgical procedure, a sample of visceral adipose tissue (50 g) will be collected and used for periodontal bacteria detection and inflammatory markers analyses. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02853734
Study type Interventional
Source Centre Hospitalier Universitaire de la Réunion
Contact Emilie TECHER
Phone +262(0)262906289
Email emilie.techer@chu-reunion.fr
Status Recruiting
Phase N/A
Start date March 12, 2019
Completion date July 2021

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