BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study

Obesity Clinical Trial

— BRIGHT  

Official title:

BRown Fat Activity Measurement With Infrared imaginG tHermography and Thermogenesis - the BRIGHT Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02790255
• Other study ID #: 2014/00721
• Status: Completed
• Phase: N/A
• Start date: November 2014
• Est. completion date: November 5, 2018

Study information

• Verified date: May 2019
• Source: Clinical Nutrition Research Centre, Singapore
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.

The infrared (IR) energy flux from activated BAT can be accurately imaged and quantified using an IR imaging device, and that this IR energy output may be correlated to the increased energy expenditure quantified by the whole body calorimeter.

Description:

The recent rediscovery of functional brown adipose tissue (BAT) in healthy adults has opened up the exciting possibility of manipulating BAT for obesity management, and it is imperative to develop BAT imaging modalities that are non-invasive and safe for repeated use. Given that heat is a specific end-product of uncoupling protein-1 (UCP-1)-mediated BAT, this study examines whether surface body temperature assessed using infrared (IR) thermography can be a non-invasive measure to accurately and precisely predict brown adipose tissue (BAT) activation upon cold stimulation, which involves verifying an semi-automated method for characterizing thermal images. In addition, this study also aims to validate the use of a whole-body calorimeter to pick up changes in energy expenditure upon cold-induced thermogenesis. Lean, healthy male volunteers will be recruited. Thermal imaging of cervical-supraclavicular BAT will be done using an IR camera to assess changes in BAT activation. Blood samples will also be drawn at regular intervals to track changes in serum metabolites upon BAT activation. All in all, this study hopes to provide more supporting evidence that IR thermography is a viable imaging modality that is non-invasive, safe and reproducible of studying BAT activity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: November 5, 2018
• Est. primary completion date: November 5, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 21 Years to 35 Years

Eligibility

Inclusion Criteria:

• Male

• Ethnic Chinese

• Age between 21 to 35 years

• Body Mass Index 18.5 to 22.9

• Normal resting blood pressure ~120/80 mmHg

• Normal fasting blood glucose level <5.5 mmol/L

Exclusion Criteria:

• Do not train for or partake in competitive sports

• Do not have any major diseases

• Not on any prescribed medication

Related Conditions & MeSH terms

• Adipose Tissue, Brown
• Energy Expenditure
• Obesity

Intervention

Other:
• Cold air

• Cold water

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Clinical Nutrition Research Centre, Singapore	Institute for Infocomm Research

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Temperature at cervical-supraclavicular region	The temperature at the cervical-supraclavicular region following cold exposure will be determined using infrared thermal imaging.	45 minutes cold exposure
Secondary	Energy expenditure during cold exposure	Energy expenditure during cold exposure will be determined using the whole-body calorimeter.	45 minutes cold exposure