Obesity Clinical Trial
Official title:
Effects of Butyrate on Insulin Resistance in Children Affected by Obesity
Butyrate is a short chain fatty acid (SCFA) produced by bacterial fermentation of undigested
starch in the gut. Butyrate carries out different effects at intestinal and extraintestinal
level, including: immune regulation with anti-inflammatory effect at intestinal and systemic
level and modulation of gut microbiota. Many of these effects result from an epigenetic
mechanism. Shown in an animal model of obesity induced by a high fat diet (HFD), that
butyrate can exercise very effective protective action against obesity through the
stimulation of intestinal satiety hormones. Shown always in murine model of obesity induced
by HFD, that butyrate is effective in preventing and treating obesity and insulin
resistance. After 5 weeks of treatment with butyrate was observed a reduction of 10.2% of
body weight, 30% of fasting glucose and 50% insulin resistance.
In an animal model of metabolic syndrome with NAFLD researchers have recently demonstrated
that the administration of butyrate is able to significantly reduce insulin resistance,
liver damage, dyslipidaemia through a modulation of the inflammatory process.
Pharmacokinetic and pharmacodynamic studies in humans show that the oral administration of
butyrate is safe and well tolerated. The peak serum levels occurs 4-6 hours after oral
administration.
All of these data makes plausible a possible positive effect on insulin resistance in the
obese child.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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