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The Impact of Bariatric Surgery Induced Weight Loss on Lung Function in Adolescents

Obesity Clinical Trial

Official title:
The Impact of Bariatric Surgery Induced Weight Loss on Lung Function in Adolescents

Clinical Trial Summary

In this prospective study we will evaluate the changes in respiratory physiology occurring in morbidly obese adolescents following bariatric surgery at Schneider Children's Medical Center of Israel (SCMCI).

Clinical Trial Description

Morbid obesity leads to restrictive as well as obstructive ventilatory defects via mechanisms that include mechanical, as well as inflammatory factors. We hypothesise that multiple breath nitrogen washout will be more sensitive to changes in small airway function than conventional lung function testing. We will invite adolescents with morbid obesity, scheduled to undergo bariatric surgery at SCMCI during 2016-2018, for pulmonary function testing, including spirometry, plethysmography, nitrogen multiple breath washout, lung transfer factor and 6 minute walk. These tests will be conducted prior to the operation as well as during follow-up appointments at 3, 6 and 12 months. We will also evaluate oxidative stress using highly sensitive C-reactive protein as surrogate marker. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02644174
Study type Observational
Source Rabin Medical Center
Contact Patrick Stafler, MD
Phone 972-54-7243623
Email pstafler@hotmail.com
Status Recruiting
Phase
Start date May 2016
Completion date January 2023
View Details
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