Obesity Clinical Trial
Official title:
The Contribution of Atrial Natriuretic Peptide in Lipid Mobilization of Subjects With Obesity, Both During Rest and Exercise
In the developing countries, obesity prevalence is on a dramatic rise. Obesity is related to
co-morbidities and as a result, obesity significantly shortens life expectancy and lowers
quality of life. To prevent this, participation in exercise or training programs is
absolutely necessary, in order to generate adipose tissue mass loss. The amount of adipose
tissue mass loss is, amongst others, dependent on lipolysis which is under endocrine
regulation by, mainly, catecholamines, insulin and atrial natriuretic peptide. However,
large variations in adipose tissue mass loss and gain are likely in obese subjects, possibly
due to a decreased lipolytic effect of these hormones (as was shown for catecholamines in
the subcutaneous adipose tissue of obese subjects). However, the relative contribution of
atrial natriuretic peptide in the lipolytic process remains elusive, particularly in
subjects with obesity, which show an increased plasma expression of atrial natriuretic
peptide.
The aim of the present study is to observe the contribution of atrial natriuretic peptide in
the subcutaneous adipose tissue of obese subjects. This will be tested by measurements of
extracellular glycerol levels (by microdialysis) in the subcutaneous adipose tissue in situ
at rest and during endurance exercise under local beta- and alpha-blockade.
Eventually, the knowledge gained from this research will contribute to the optimization of
exercise programs for people with obesity.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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