Genetic Analysis of Childhood Obesity

Obesity Clinical Trial

— OSV  

Official title:

Genetic Analysis of Childhood Obesity

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02326480
• Other study ID #: RC-P0036
• Status: Recruiting
• Start date: January 2015
• Est. completion date: June 2021

Study information

• Verified date: March 2020
• Source: Lille Catholic University
• Contact: Amélie Lansiaux, MD, PhD
• Email: lansiaux.amelie[@]ghicl.net
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: June 2021
• Est. primary completion date: December 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Months to 18 Years

Eligibility

Inclusion criteria:

• BMI > curve of IOTF 30 (International Obesity Task Force)

• Age: between 6 months old and 18 years old

• Child presenting syndromic, isolated or familial obesity.

Exclusion Criteria:

• Common obesity

• Impossibility for blood sampling

• Impossibility to receive information

• Participation refusal of one of the parents

• Refusal to sign the informed consent

• Neither Healthcare coverage nor insurance

Related Conditions & MeSH terms

• Obesity
• Pediatric Obesity

Intervention

Other:
• Identification of genetic causes of obesity
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition

Locations

Country	Name	City	State
France	Hôpital Saint Vincent de Paul	Lille

Sponsors (2)

Lead Sponsor	Collaborator
Lille Catholic University	Institut Pasteur de Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To identify the number of mutations or genes involved in genetic causes of Child obesity	Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes	first day of enrollement
Secondary	To identify the number of mutations in the population		first day of enrollement
Secondary	To identify the number of new mutations present in the children's DNA and absent from their parents' genomes	This approach will allow the identification of specific mutations that are present only in affected children but not in their parents	first day of enrollement
Secondary	To determine number of phenotypes associated to the child obesity genotype		first day of enrollement