Obesity Clinical Trial
Official title:
Legume Diet Satiety and Weight Loss Pilot Study
This pilot study is designed to test the effects of a high legume (dried bean) diet on hunger and other indicators of health over the course of eight weeks, compared to a more conventional healthy diet.
The goal of the currently proposed study is to conduct a randomized controlled feeding pilot
study within a more diverse population also at high risk for colorectal carcinoma (CRC) to
evaluate whether a high-legume diet will result in increased satiety and in turn will
facilitate reduced energy intake and weight loss compared to a control diet provided under
similar conditions. In addition, explore potential beneficial effects of the high-legume diet
on gastric emptying and circulating levels of appetite-regulating hormones and other
biomarkers. Dietary behaviors that are even moderately more satiating over time have the
potential to enhance weight loss and could lead to a significant public health impact among
populations at high risk for colorectal carcinoma (CRC) and other chronic diseases.
Towards the end of the study, the participants will do an additional test, looking at how
long food takes to pass through the digestive system using a SmartPill capsule. The SmartPill
is a pill about the size of a large multivitamin that can measure pH, pressure, and
temperature changes, which it uses to assess where in the digestive tract it is. The
participant swallows the pill, and carries around a receiver that is about the size of a deck
of cards for the next 3-5 days. The SmartPill is expelled, and the receiver notifies the
participant that they can return the receiver to the study personnel.
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