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Effects of Glucagon Administration on Energy Expenditure — GLEE  

Obesity Clinical Trial

Official title:
A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Protection (EGP).

Clinical Trial Summary

The purpose of this study is to collect data to help researchers better understand the effects of glucagon on the amount of calories burned.

Clinical Trial Description

1. To compare the effect of prolonged hyperglucagonemia to that of acute hyperglucagonemia on energy expenditure in healthy subjects using room indirect calorimetry in the setting of octreotide-mediated prevention of plasma insulin excursions.

2. To compare the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on EGP in healthy subjects in the setting of octreotide-mediated prevention of plasma insulin excursions.

3. To determine the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on rates of substrate oxidation, fibroblast growth factor21 and metabolites of interest. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02237053
Study type Interventional
Source Translational Research Institute for Metabolism and Diabetes, Florida
Contact
Status Completed
Phase Phase 1
Start date September 2014
Completion date June 2016
View Details
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