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Influence of Aromatase Inhibition on Hepatic- and Cardiac Function in Severe Obese Men — HEPAROB  

Obesity Clinical Trial

Official title:
Influence of the Aromatase Inhibitor Letrozole on Heart and Liver Function in Obese Men

Clinical Trial Summary

It seems plausible that increased aromatase activity in obese men, as a result of a larger fat mass, is responsible for decreased levels of testosterone. Therefore aromatase inhibition increases testosterone levels, which may affect hepatic and cardiac function. In this intervention study two groups of hypogonadal obese men are compared. Group A is treated with Letrozole 2.5 mg (aromatase inhibitor) once every two days during four months; a group with normal testosterone and low oestrogen concentrations. Group B is treated with placebo once every two days during four months; this group will retain low testosterone - and high oestrogenic concentrations. The primary objective of the study is to evaluate effects of changed sex steroids in obese men on hepatic and cardiac function.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02097680
Study type Interventional
Source University Hospital, Ghent
Contact
Status Completed
Phase Phase 4
Start date December 2013
Completion date June 2015
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