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Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus) — Columbus  

Obesity Clinical Trial

Official title:
Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation in Both Skeletal Muscle and Adipose Tissue

Clinical Trial Summary

The purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the beneficial effects of exercise.

Clinical Trial Description

Study Objectives: 1. To identify specific changes in messenger ribonucleic acid (mRNA)/micro ribonucleic acid (miRNA) expression in muscle associated with higher or lower relative measures of mitochondrial capacity and fat oxidation. 2. To identify secreted factors/miRNAs that specifically relate to the metabolic response of muscle and that are present after a single initial bout of exercise. 3. To collect the appropriate clinical samples (muscle and adipose tissue, plasma/serum) to enable validation of myokines associated with changes in oxygen consumption/mitochondrial content via in vivo and in vitro discovery efforts. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01911091
Study type Interventional
Source AdventHealth Translational Research Institute
Contact
Status Active, not recruiting
Phase N/A
Start date July 2013
Completion date June 2024
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