Obesity Clinical Trial
Official title:
Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women
The United States has the highest prevalence of obesity among all countries surveyed in 2012
by the Organization for Economic Cooperation and Development. Maternal obesity is linked
with anovulation, menstrual cycle abnormalities, subfertility, fetal loss, obstetrical
complications and congenital anomalies. Changes in reproductive hormones and diminished
oocyte quality have also been demonstrated. A gap of knowledge exists as the mechanisms
underlying these harmful effects are poorly understood and no specific treatments exist.
This proposal will test the hypothesis that dietary omega-3 FA will improve the output of
hypothalamicpituitary- ovarian axis in obese women. The investigators will perform paired
assessments before and after supplementation in 10 obese and 10 normal weight women. To test
the pituitary and hypothalamic output, the investigators will examine the luteinizing
hormone (LH) and follicle-stimulating hormone (FSH) responsiveness during frequent blood
sampling. To test the corpus luteum function, the investigators will examine urinary
reproductive hormones (E1c, estrone conjugates, and Pdg, pregnanediol glucuronide) over an
entire menstrual cycle. Our ultimate goal is to collect preliminary data for an adequately
powered randomized control trial.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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