Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity

OBESITY Clinical Trial

Official title:

Observational Retrospective Study on Correlation Between ET-1 and Ad in Obese Children

Clinical Trial Details — Status: Unknown status

Administrative data

• NCT number: NCT01750333
• Other study ID #: OBETAD-01
• Status: Unknown status
• Phase: N/A
• First received: December 12, 2012
• Last updated: December 12, 2012
• Start date: April 2012
• Est. completion date: March 2013

Study information

• Verified date: December 2012
• Source: Montagnani, Monica, M.D., Ph.D.
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

Recruitment information / eligibility

• Status: Unknown status
• Enrollment: 60
• Est. completion date: March 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 13 Years

Eligibility

Inclusion Criteria:

• Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.

Exclusion Criteria:

• presence of renal, liver and/or cardiovascular diseases;

• hypertension;

• metabolic and/or endocrine disorders;

• genetic syndromes;

• histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study

Related Conditions & MeSH terms

• Endothelial Dysfunction
• Insulin Resistance
• OBESITY

Locations

Country	Name	City	State
Italy	University of Bari Medical School - Dept Biomedical Sciences and Human Oncology	Bari

Sponsors (1)

Lead Sponsor	Collaborator
Monica Montagnani

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation between serum levels of ET-1 and Ad in lean, overweight and obese children		12 months